The Authors Reply We greatly appreciate the letter to the editor submitted by Ozcan et al. As brain natriuretic peptide (BNP) can be a surrogate marker for left atrial appendage dysfunction and cardiogenic stroke in patients with acute ischemic stroke (1), their suggestion regarding the relationship between BNP and D-dimer may be useful for evaluating the fundamental thrombogenic mechanisms in ...

In teleost fish and tetrapods, the natriuretic peptide (NP) family consists of ANP (atrial natriuretic peptide), BNP (brain natriuretic peptide) and VNP (ventricular natriuretic peptide) that are secreted from the heart, and C-type natriuretic peptide (CNP) that is found in the brain. However, CNP is the only NP identified in the heart and brain of elasmobranchs, suggesting that it is the ances...

We tested the hypothesis that natriuretic peptide receptors (NPRs) that are coupled to cGMP production act in a similar way to nitric oxide (NO) by enhancing acetylcholine release and vagal-induced bradycardia. The effects of enzyme inhibitors and channel blockers on the action of atrial natriuretic peptide (ANP), brain-derived natriuretic peptide (BNP), and C-type natriuretic peptide (CNP) wer...

The rationale for the treatment with various pharmacologic agents administered in the management of both chronic and acute decompensated heart failure (ADHF) are based on our understanding of underlying pathophysiology of the patient’s diseases. Recently, the management of HF has shifted from traditional drugs that are administered to ameliorate the gross hemodynamic manifestations of volume ov...

BACKGROUND It is unclear whether coronary artery stenosis affects the secretion of N-terminal pro-brain natriuretic peptide (NT-proBNP) and brain natriuretic peptide (BNP) from the heart independent of ventricular dysfunction. Therefore, this study evaluated the relationship between BNP and NT-proBNP secretion, plasma levels and the severity of coronary artery stenosis in patients with stable c...

Clinical heart failure, often the result of myocardial infarction, may be preceded by a period of compensated left ventricular impairment. There is substantial need for an experimental model that reflects this human condition. In sheep, coronary artery ligation produced consistent left ventricular anteroapical myocardial infarctions resulting in chronic (5 wk), stable hemodynamic changes compar...

We determined the nucleotide sequence of mouse natriuretic peptide receptor-A (NPR-A) cDNA and compared the revised deduced amino acid sequence with those of rat and human NPR-A. The ligand selectivity of these three receptor/guanylyl cyclases was examined by whole-cell stimulation of cGMP production. The 28-amino acid atrial natriuretic peptide (ANP) has only one difference among these three s...

The biological significance of atrial natriuretic peptide (ANP) has been studied exhaustively from a physiological, pathological, pharmacological, and diagnostic standpoint. This member of the natriuretic peptide family exerts a profile of complementary effects in the cardiovascular system, including natriuretic, diuretic, vasodilator, anti–renin–angiotensin–aldosterone system, antihypertrophic...

colleagues evaluated brain natriuretic peptide (BNP) and N-terminal prohormone brain natriuretic peptide (NT-proBNP) serial measurements as predictive of 30-day and 1-year mortality and readmission in patients admitted to the emergency department for acute decompen sated heart failure (ADHF) [1]. Th e usefulness of measuring BNP and NT-proBNP in the diagnosis and management of congestive heart ...