We recently showed by electron microscopy that the postsynaptic density (PSD) from hippocampal cultures undergoes rapid structural changes after ischemia-like conditions. Here we report that similar structural changes occur after delay in transcardial perfusion fixation of the mouse brain. Delay in perfusion fixation, a condition that mimics ischemic stress, resulted in 70%, 90%, and 23% increa...

Importance: The Defense and Veterans Brain Injury Center reported 358,088 mild traumatic brain injury (mTBI) among U.S. service members worldwide between the years 2000 2020. with mTBI have higher rates of Post-Traumatic Stress Disorder (PTSD), depressive disorder, substance use anxiety suicide than their healthy counterparts. Currently, there is no effective treatment for mTBI. Objective: To a...

Background The Pennes' perfusion term in the Pennes bioheat transfer equation (BHTE) depicts the rate at which blood flow removes heat from a point and can play an important role in tissue heat dissipation. Because tissue perfusion is known to change over the course of a thermal therapy treatment [1, 2], the ability to perform multiple flow assessments to detect perfusion changes during magneti...

BACKGROUND AND PURPOSE Little is known about the pathological mechanism or the anatomic and functional imaging features related to the clinical manifestations in patients with brain AVM. The purpose of this pilot study was to describe the pattern of whole-brain PCT abnormalities in brain AVMs and their potential to differentiate underlying pathomechanisms. MATERIALS AND METHODS Whole-brain PC...

Introduction Perfusion is the term applied to capillary blood flow in tissue. Since the blood carries oxygen and nutrition to the tissue through the capillaries, perfusion is important in maintaining tissue viability. The study of brain perfusion has clinical applications due to the changes in perfusion associated with several neurological diseases. Diagnosis, lesion characterisation and follow...

The means of treatment of ICU patients is to sustain perfusion and O2 delivery to all major organs to avoid organ damage. On neurosurgical ICU the most important factor is to prevent secondary brain injury after traumatic brain injury (TBI) or subarachnoid hemorrhage (SAH) due to ischemia or low tissue oxygenation. To minimize the risk of brain ischemia, standard treatment guidelines have been ...

OBJECTIVE Demonstrate brain perfusion changes due to neuronal activation after functional electrical stimulation (FES). METHOD It was studied 14 patients with hemiplegia who were submitted to a program with FES during fourteen weeks. Brain perfusion SPECT was performed before and after FES therapy. These patients were further separated into 2 groups according to the hemiplegia cause: cranial ...

BACKGROUND Studies of brain perfusion during migraine without aura attacks have inconsistent results. METHODS Arterial spin labeling MRI, a non-invasive quantitative perfusion technique, was used to prospectively study a spontaneous untreated migraine without aura attack and a headache-free period. Image analysis used FSL and MATLAB software; Group analysis used permutation methods for perfus...

Experimental results for changes in brain temperature during functional activation show large variations. It is, therefore, desirable to develop a careful numerical model for such changes. Here, a three-dimensional model of temperature in the human head using the bioheat equation, which includes effects of metabolism, perfusion, and thermal conduction, is employed to examine potential temperatu...

BACKGROUND AND PURPOSE Early diagnosis of perfusion deficits in patients with acute stroke could guide treatment decisions and improve prognosis. We investigated the sensitivity of perfusion CT studies using parametric time-to-peak maps to assess ischemic brain tissue with respect to early infarct signs on native CT scans. METHODS First-pass, single-section perfusion CT was performed in 20 pa...