Src, a nonreceptor tyrosine kinase, is involved in a number of cancer-related signaling pathways and aberrantly activated in biliary tract cancer (BTC). This study aimed to elucidate the potential role of Src as a therapeutic target in BTC. We tested bosutinib, an orally active c-Src/Abl kinase inhibitor, alone or in combination with cytotoxic agents using 9 human BTC cell lines: SNU-245, SNU-3...

The microwave solvothermal reaction of nickel nitrate with trimesic acid provided the title compound, [Ni(3)(BTC)(2)(H(2)O)(12)](n) (BTC = benzene-1,3,5-tricarboxyl-ate anion, C(9)H(3)O(6)), which is a metal coordination polymer composed of one-dimensional zigzag chains. The crystal under investigation was ramecically twinned with an approximate twin domain ratio of 1:1. In the asymmetric unit,...

Overdriving technique enlarges the desired change of the pixel value,the error in general compression methods is enlarged at the same time. Therefore, we propose a novel Adaptive Quantization Coding (AQC) to reduce the error in compression for overdriving technique reducing motion blur. Considering hardware implementation, we develop a hybrid image coding which uses color transform first, and t...

There are several compounds for which there exists a disconnect between porosity as predicted by crystallography and porosity measured by gas sorption analysis. In this paper, the Zn-based analogue of Cu(3)(btc)(2) (HKUST-1), Zn(3)(btc)(2) (Zn-HKUST-1; btc = 1,3,5-benzenetricarboxylate) is investigated. Conventional analysis of Zn-HKUST-1 by powder X-ray diffraction and gas sorption indicates r...

Our previous data demonstrated that type II cGMP-dependent protein kinase (PKG II) inhibited epidermal growth factor (EGF)-induced MAPK/ERK/JNK-mediated signal transduction through inhibiting the phosphorylation/activation of the epidermal growth factor receptor (EGFR). Since the EGFR also binds with several other ligands as well as EGF, the present study was designed to investigate whether PKG...

Mitosis dysregulation is common in cancers. This study explored the nuclear expression patterns and prognostic significance of mitotic regulatory proteins, including Aurora kinases, survivin, and p53, in biliary tract cancer (BTC). Archival tumor samples from 161 BTC patients who underwent surgery were tested for the expression of Aurora-A, Aurora-B, survivin, and p53 by immunohistochemistry. T...

Decline in cognitive functions, including hippocampus-dependent spatial memory, is commonly observed at a later stage of aging (e.g., >20 months old in rodents) and typically studied after a discrete learning event. How normal aging, particularly at an early stage, affects the modulatory aspect of memory persistence is underinvestigated. Previous studies in young animals show that weak, fading ...

The aim of this study was to investigate the molecular and protein expression pattern of markers of stemness phenotype and its clinicopathological significance in human biliary tract cancer (BTC). Human BTC cell lines (CCLP-1, Egi-1, MzChA-1, MzChA-2, SkChA-1, TFK-1 and GBC) were analyzed in vitro and in xenotransplanted animals for expression of markers of stemness and compared to tissue micro...

A novel heteroleptic Ru II complex (BTC-2) employing 5,5 ′ -(2,2 ′ -bipyridine4,4 ′ -diyl)bis (thiophene-2-carboxylic acid) (BTC) as the anchoring group and 4,4 ′ dinonyl-2,2 ′ -bipiridyl and two thiocyanates as ligands is prepared. The photovoltaic performance and device stability achieved with this sensitizer are compared to those of the Z-907 dye, which lacks the thiophene moieties. For thin...