نتایج جستجو برای: breakage function

تعداد نتایج: 1219489  

Journal: :British medical journal 1971
E Boyd U Abdulla I Donald J E Fleming A J Hall M A Ferguson-Smith

Human lymphocyte cultures were examined for chromosome damage after exposure to ultrasound. Control and treated slides were scored "blind" and showed no evidence of damage due to ultrasound. Neither was there evidence of chromosome damage in blood cultures from six infants whose mothers had ultrasound during pregnancy when compared with that from six infants whose mothers had not. Our results s...

Journal: :The Journal of biological chemistry 2012
Boxu Yan Daniel Boyd Timothy Kaschak Joni Tsukuda Amy Shen Yuwen Lin Shan Chung Priyanka Gupta Amrita Kamath Anne Wong Jean-Michel Vernes Gloria Y Meng Klara Totpal Gabriele Schaefer Guoying Jiang Bartek Nogal Craig Emery Martin Vanderlaan Paul Carter Reed Harris Ashraf Amanullah

Upper hinge is vulnerable to radical attacks that result in breakage of the heavy-light chain linkage and cleavage of the hinge of an IgG1. To further explore mechanisms responsible for the radical induced hinge degradation, nine mutants were designed to determine the roles that the upper hinge Asp and His play in the radical reactions. The observation that none of these substitutions could inh...

Journal: :Bio Systems 2012
Jaume Baixeries Antoni Hernández-Fernández Ramon Ferrer-i-Cancho

Recently, a random breakage model has been proposed to explain the negative correlation between mean chromosome length and chromosome number that is found in many groups of species and is consistent with Menzerath-Altmann law, a statistical law that defines the dependency between the mean size of the whole and the number of parts in quantitative linguistics. Here, the central assumption of the ...

Journal: :The Journal of biological chemistry 1989
J R Bertrand J J Vasseur A Gouyette B Rayner J L Imbach C Paoletti C Malvy

We have studied the kinetics of breakage of apurinic (AP) sites by the intercalating agent 9-aminoellipticine using fluorimetric methods with single (ss)- and double (ds)-stranded apurinic DNA. In order to understand the chemical process, high performance liquid chromatography was used to follow the reaction kinetics with the apurinic oligonucleotide model T(AP)T. The unstable intermediate, whi...

Journal: :Cancer research 1984
L Szmigiero L C Erickson R A Ewig K W Kohn

The effects of 3,6-diaziridinyl-2,5-bis(carboethoxyamino)-1,4-benzoquinone (diaziquone; AZQ) on various cell types were studied in relation to two chemical reactivities that this drug would be expected to have intracellularly. AZQ can undergo a reduction-oxidation cycle of the quinone function; this could generate free radicals which could produce DNA damage, especially DNA strand scission. The...

Ali Dehghani Ahmadabadi Mohammad Noparast Mohammad Reza Soltani Seyyed Ziaeddin Shafaei Ziaeddin Pourkarimi

Simulation of grinding circuits has being performed from 30 years ago and is also to be more complete and powerful approach with improvement of mathematical models which simulate various processing units/machines. The modeling and simulation of various mineral processing circuits are presently performed. In order to simulate the present grinding circuits of Esfordi Phosphate processing plant, a...

2016
Khushboo Rastogi Mohammed Shabeel Puliyakodan Vikas Pandey Sunil Nath Ravikrishnan Elangovan

In this work, we analysed processive sliding and breakage of actin filaments at various heavy meromyosin (HMM) densities and ATP concentrations in IVMA. We observed that with addition of ATP solution, the actin filaments fragmented stochastically; we then determined mean length and velocity of surviving actin filaments post breakage. Average filament length decreased with increase in HMM densit...

2016
Fekret Osman Jong Sook Ahn Alexander Lorenz Matthew C. Whitby

DNA double-strand break (DSB) repair by homologous recombination (HR) involves resection of the break to expose a 3' single-stranded DNA tail. In budding yeast, resection occurs in two steps: initial short-range resection, performed by Mre11-Rad50-Xrs2 and Sae2; and long-range resection catalysed by either Exo1 or Sgs1-Dna2. Here we use genetic assays to investigate the importance of Exo1 and t...

Journal: :Geotechnics 2022

Particle breakage in soils is a well-recognised behaviour. Conventional methods for quantifying the process rely on calculating area between particle size distribution (PSD) curves produced before and after crushing. A key aspect of understanding across different size/sieve fractions. Grading entropy coordinates allow representation any PSD to be shown as single point Cartesian plane are able t...

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