The objective was to evaluate whether norepinephrine (NE) and other hormonal factors have direct effects on protein degradation in brown fat cells. NE inhibited proteolysis by 35-45% in mouse brown adipocytes differentiated in culture. Insulin also inhibited protein degradation but significantly less than NE, whereas glucagon and leptin had no effect. The inhibitory effect of NE was partially a...

b 3 -adrenoceptors are involved in metabolism, gut relaxation, and vascular vasodilation. However, their existence and role in the human heart have not been documented. We investigated the effects of several b -adrenoceptor agonists and antagonists on the mechanical properties of ventricular endomyocardial biopsies. In the presence of nadolol, a b 1 and b 2 -adrenoceptor antagonist, isoprenalin...

Brown rice traits are critical to both grain yield and quality. In the present study, chromosome segment substitution lines (CSSLs) population derived from a cross between japonica Koshihikari indica Nona Bokra was used analyze brown length (BRL), width (BRW), length–width ratio of (BLWR), thickness (BRT), perimeter (BRP), area (BRA), thousand-grain weight (BRGW), (BRR), taste value (BTV), wate...

Though two isoforms of nitric oxide synthase, iNOS and eNOS, were reported in adipocytes, the role of NO in adipose tissue is still ambiguous. The aims of the present study were 1) to follow the effect of bacterial lipopolysaccharide (LPS), on 24 h-lipolysis in rat epididymal adipocyte culture in relation to iNOS stimulation; 2) to compare LPS-induced NO effects with exogenously NO, delivered a...

Peroxisome proliferator-activated receptor-g (PPARg), a member of the nuclear hormone receptor superfamily, plays an essential role in the mediation of the actions of antidiabetic drugs known as thiazolidinediones (TZDs). PPARg activates many target genes involved in lipid anabolism including the adipocyte fatty acid binding protein (aP2). In this study, induction of aP2 gene expression by PPAR...

The role of b3and other putative atypical b-adrenoceptors in human white adipocytes and right atrial appendage has been investigated using CGP 12177 and novel phenylethanolamine and aryloxypropanolamine b3-adrenoceptor (b3AR) agonists with varying intrinsic activities and selectivities for human cloned bAR subtypes. The ability to demonstrate b1/2AR antagonist-insensitive (b3 or other atypical ...

1. The pharmacological features of rat white adipocyte beta-adrenoceptor subtypes were investigated by saturation and beta-agonist competition studies with [3H]-CGP 12177 and by lipolysis induced by beta-agonists as well as their inhibition by CGP 20712A (selective beta 1-antagonist) and ICI 118551 (selective beta 2-antagonist) in an attempt to establish a relationship between the functionality...

Liver fibrosis is the common pathological outcome for the majority of chronic liver diseases. Interleukin-10 (IL-10) is a cytokine that downregulates proinflammatory responses and has a modulatory effect on liver fibrogenesis. However, little is known regarding the effect of rat interleukin‑10 (rIL‑10) gene by hydrodynamics-based transfection (HBT) on liver fibrosis in rats. The aim of this stu...

BRL 26921 is a protected plasminogen-streptokinase complex with selective affinity for thrombus. When given intravenously within three hours of the onset of a first acute myocardial infarction angiographic patency of the infarct related vessel was seen in all 16 patients receiving the active drug compared with only two of 16 receiving a placebo. There was relative sparing of left ventricular fu...

Abstract—This paper is concerned with the H∞ filtering for sampled-data systems. First, an event-based data packet processor is introduced to release the sampled measurement outputs only if an event condition is violated. As a result, the communication resources can be significantly saved while the desired system performance can be preserved. Second, the resulting filtering error system is mode...