Described is an efficient heterologous expression system for Sulfolobus solfataricus ADH-10 (Alcohol Dehydrogenase isozyme 10) and its use in the dynamic reductive kinetic resolution (DYRKR) of 2-arylpropanal (Profen-type) substrates. Importantly, among the 12 aldehydes tested, a general preference for the (S)-antipode was observed, with high ee's for substrates corresponding to the NSAIDs (non...

and indeed many of the other analyses reported in our paper do not suffer from potential bias due to weak instruments. Hartwig and Davies did, however, suggest that we could have used estimates from an external source to obtain less biased results in our MR-Egger analyses. Whereas we agree that this would be good practice in most situations, we do not feel that it would have been appropriate in...

A complex of zirconocene with two rq2-alkynyl ligands is described. This complex is the first isolated example of the postulated intermediate in the zirconocene-mediated reductive coupling of alkynes. The development of a Bergman cyclization controlled by metal-ligand interactions is described. Upon complexation with palladium or platinum, phosphine-substituted enediynes rearrange to the aromat...

Hartwig Weber, „Von der verführten Kinder Zauberei“. Hexenprozesse gegen im alten Württemberg, Sigmaringen (Jan Thorbecke) 1996. 274 S.