Burns commonly occur in children and their first aid remains inadequate despite burn prevention programmes. While scald injuries predominate, contact and flame burns remain common. Although typically less severe injuries overall than those in adults, hypertrophic scarring complicating both the burn wound and even donor sites occur more frequently in children. The heterogeneous nature of burn wo...

We read with great interest the highly educational review by Rowan et al. on wound healing and treatment of burn patients [1]. As discussed in detail by the authors, burn injury is inextricably linked with some states of inflammation. Acute-phase activation of crucial immune processes is imperative for survival and initiation of wound healing, otherwise inflammation may become detrimental when ...

Burns are one of the most common devastating forms of trauma. Burn patients are ideal hosts for opportunistic infections [1]. Thermal injury causes instant coagulative necrosis, which rapidly becomes a favourable niche for bacterial colonisation and proliferation. The eschar provides a devitalised, protein rich environment, which further benefits bacterial proliferation through its exclusion fr...

Children, especially younger ones, form a risky group among burned patients. A severe burn injury is not only a life threatening problem for injured children, but may have serious physical, psychosocial and financial effects on them, their families and the society. Although the number of burned victims among children has been decreasing in most of the European countries, including Croatia, duri...

The ability of Candida albicans to infect thermally injured mice was studied. Female mice were either left unburned or given a 20% total body surface area 2-s or 7-s scald burn. The wound or skin surface was then inoculated with a human burn wound isolate of C. albicans. At 4 h postburn, approximately 10(2) to 10(3) CFU/g of tissue could be recovered from the skin of burned and unburned animals...

BACKGROUND Burn-induced inflammation leads to impaired immune responses resulting in increased morbidity and mortality. T-cells are central in the immune response and circulating CD4 and CD8 T-cells have been used to evaluate immune status; however, the role of these T-cell subsets in the burn wound is unknown. METHODS Male C57BL/6 mice were subjected to a major 3rd degree scald burn or sham ...