A form of alpha-galactosylceramide, KRN7000, activates CD1d-restricted Valpha14-invariant (Valpha14i) natural killer (NK) T cells and initiates multiple downstream immune reactions. We report that substituting the C26:0 N-acyl chain of KRN7000 with shorter, unsaturated fatty acids modifies the outcome of Valpha14i NKT cell activation. One analogue containing a diunsaturated C20 fatty acid (C20:...

dutch elm disease is one of the most destructive vascular wilt diseases in the world. ophiosatoma ulmi and o. novo-ulmi had been the most important causal agents of the dutch elm disease in the last century. so, in order to manage of disease, their identification and distinction is necessary. these fungal species were distinguished based on morphological, physiological and molecular characters....

Background: The aim of the present study is the determination of the effects of seasonal variations on the proximate analysis, cholesterol content and fatty acid compositions of Helix aspersa. Materials and Methods: Garden snails (Helix aspersa) were picked up by hand from the Central Anatolia Region of Turkey, in autumn (November) and spring (April) in 2011. Fatty acid methyl esters (FAMEs) an...

BACKGROUND/AIM Clofarabine is transported into leukemic cells via the equilibrative nucleoside transporters (hENT) 1 and 2 and the concentrative nucleoside transporter (hCNT) 3, then phosphorylated by deoxycytidine kinase (dCK) and deoxyguanosine kinase (dGK) to an active triphosphate metabolite. Cytarabine uses hENT1 and dCK for its activation. We hypothesized that cytarabine-resistant leukemi...

The electronic correlations on a C20 molecule, as described by an extended Hubbard Hamiltonian with a nearest-neighbor Coulomb interaction of strength V , are studied using quantum Monte Carlo and exact diagonalization methods. For electron-doped C20, it is known that pair binding arising from a purely electronic mechanism is absent within the standard Hubbard model (V = 0). Here we show that t...

The rich partial textures and beating of the traditional tibetan bowl have tantilized listeners for centuries. In this paper we propose a real-time physical model of a singing bowl meant for use in performance. In order to be able to use it in a performance context, we control it using a rubboard musical controller. We feel that the mapping between the two instruments is uniquely natural and co...

We examine the geometry of a complete, negatively curved surface isometrically embedded in R3. We are especially interested in the behavior of the ends of the surface and its limit set at infinity. Various constructions are developed, and a classification theorem is obtained, showing that every possible end type for a topologically finite surface with at least one bowl end arises, as well as al...

BACKGROUND Serum free fatty acids (FFAs) are correlated with pathological status, and change in serum FFA levels may be associated with thyroid diseases. MATERIALS AND METHODS In this study, 664 serum samples from 322 healthy controls, 129 patients with benign thyroid disease (BTD), and 213 patients with thyroid cancer (TC) were collected. Chip-based direct-infusion nanoelectrospray-mass spec...

The objective of the present study was to investigate the mobilization of individual fatty acids from human white fat cells. Mammary adipose tissue from eight healthy non-obese women in their normal dietary state was collected, and isolated adipocytes were incubated with lipolytic agents. The mobilization of 34 individual fatty acids was measured by comparing the composition of non-esterified f...