Background: Alcohol use disorder poses a huge burden with only handful of approved drugs. AUD is associated impaired decision-making that leads to compulsive drinking despite negative consequences. A drug decreases alcohol consumption as well improves may thus prove more useful. This study was planned evaluate the effect two drugs, Celastrus paniculatus and memantine on preference decision impa...

Abstract Background Studies performed in multiple preclinical models support the contribution of Ca2+-dependent cysteine proteases calpains to ventricular remodelling and heart failure (HF). However, pharmacological calpain inhibition has not yet been tested patients with HF mainly due limitations available inhibitors. Purpose To determine effect NPO-2270 (NPO), a new ketoamide derivative inhib...

The interplay of environmental and genetic factors may lead to a spectrum of physiological and behavioral outcomes. How environmental stress factors interact with the diverse mouse genomes is still poorly understood and elucidating the underlying interactions requires specific stress models that can target integrated physiological systems. Here, we employ behavioral tests and whole-body plethys...

Abstract Background and Aims The peroxisome proliferator-activated receptor-γ (PPARγ) agonists have been shown to dampen TGF-β signaling suppress miR-130a in VSMCs also profibrotic miR-21-5p the kidney. We recently demonstrated that pioglitazone ameliorates established renal fibrosis by suppressing STAT3 EGR1 [1], but its effect on has not investigated. Thus, we aimed study how chronic oral tre...

NB, being a highly metastatic cancer, is one of the leading causes cancer-related deaths in children. Increased disease recurrence and clinical resistance patients with high-risk NBs (HR-NBs) result poor outcomes lower overall survival. However, paucity appropriate vivo models for HR-NB metastasis has limited investigations into underlying biology metastasis. This study was designed to address ...

Postmenopausal women represent a vulnerable population towards endocrine disruptors due to hormonal deficit. We previously demonstrated that chronic exposure of ovariectomized C57Bl6/J mice fed high-fat, high-sucrose diet low-dose mixture chemicals with one dioxin, polychlorobiphenyl, phthalate, and bisphenol A triggered metabolic alterations in the liver but intestine was not explored. Yet, ga...

Verapamil is the first-line preventive medication for cluster headache, an excruciating disorder with strong circadian features. Whereas second- and third-line preventives include known modulators, such as melatonin, corticosteroids, lithium, effects of verapamil are poorly understood. Here, we characterize features using both in vitro vivo models. In Per2::LucSV reporter fibroblasts, treatment...