Abstract Herbicide resistance is a worldwide problem in weed control. This prompts researchers to look for new modes of action slow down the evolution herbicide-resistant weeds. research aims determine herbicidal thiazolo[3,2-a]pyrimidines derivatives, which are well known as antihypertensive drugs. The phytotoxic effects ten compounds were investigated using leaf disc discoloration test and se...

Certified Registered Nurse Anesthetists administer numerous drugs to surgical patients who may be on a wide and varied pharmacological regimen. It is important that the nurse anesthetist be aware of potential drug-drug interactions. The purpose of this study is to assess the in vitro metabolic reactions of midazolam in the presence of the calcium channel blockers verapamil and nicardipine in he...

Ca(2+) influx via voltage-dependent CaV1/CaV2 channels couples electrical signals to biological responses in excitable cells. CaV1/CaV2 channel blockers have broad biotechnological and therapeutic applications. Here we report a general method for developing novel genetically encoded calcium channel blockers inspired by Rem, a small G-protein that constitutively inhibits CaV1/CaV2 channels. We s...

In human hypertrophic cardiomyopathy and hypertension associated ventricular hypertrophy, chronic use of calcium channel blockers results in a significant regression of hypertrophy. The main objective of this study was to test the hypothesis that modulation of calcium influx through the voltage-sensitive L-type Ca2+ channel directly affects myocardial hypertrophy. Agents that modified calcium i...