We report a comprehensive analysis of sequence features that allow for the production of autonomous human heavy chain variable (V(H)) domains that are stable and soluble in the absence of a light chain partner. Using combinatorial phage-displayed libraries and conventional biophysical methods, we analyzed the entire former light chain interface and the third complementarity determining region (...

OBJECTIVE To retrospectively compare clinical outcomes associated with 3 commercially available antivenom products (2 F[ab']2 and 1 IgG product) in dogs crotalid envenomation. ANIMALS 282 evidence of envenomation treated at a single high-volume private emergency facility southwestern Arizona from 2014 to 2018. PROCEDURES Data were collected on all regarding signalment, coagulation test results,...

Hemiscorpius lepturus is the most dangerous scorpion species, endemic in Khuzestan province and other southwestern areas of Iran, causing morbidity and mortality in children and adults. The efficacy of the antivenom for reversal of manifestation caused by venom of this scorpion is a controversial issue. In the present work, H. lepturus venom (1500 µg/kg) was subcutaneously injected into two ...

There is limited information on the cross-neutralisation of neurotoxic venoms with antivenoms. Cross-neutralisation of the in vitro neurotoxicity of four Asian and four Australian snake venoms, four post-synaptic neurotoxins (α-bungarotoxin, α-elapitoxin-Nk2a, α-elapitoxin-Ppr1 and α-scutoxin; 100 nM) and one pre-synaptic neurotoxin (taipoxin; 100 nM) was studied with five antivenoms: Thai cobr...

Snakebite antivenom is a 120 years old invention based on polyclonal mixtures of antibodies purified from the blood of hyper-immunized animals. Knowledge on antibody recognition sites (epitopes) on snake venom proteins is limited, but may be used to provide molecular level explanations for antivenom cross-reactivity. In turn, this may help guide antivenom development by elucidating immunologica...

How to Cite this Article: Kohli S, Bhatia S, Sexana K, Kalsi R, Rajeshwari K, Arora M. Discolouration of Polymethyl Methacrylate versus bis‐acrylic based Provisional Crown and Bridge Dental Resins: Effect of Storage Me‐ dia and Duration. Ann Med Health Sci Res. 2017; 7: 200‐202 This is an open access article distributed under the terms of the Creative Commons Attribution‐NonCommercial‐ShareAlik...

Treatment of systemic envenoming in snake-bite victims has, in the past, depended almost entirely on the individual clinician’s experience in assessing the severity of envenoming. The ef® cacy of treatment is obviously related to the neutralizing potency of the antivenom used, the route by which it is administered and the dose. The development of enzyme immunoassays has permitted a more scienti...

Coral snakes (Micrurus spp.) are the main representatives of the Elapidae in South America. However, bites by these snakes are uncommon. We retrospectively reviewed the data from 11 individuals bitten by coral snakes over a 20-year period; four were confirmed (snake brought for identification) and seven were highly suspected (neuromuscular manifestations) cases of elapid envenoming. The cases w...

OBJECTIVE To assess the efficacy and safety of low dose adrenaline injected subcutaneously to prevent acute adverse reactions to polyspecific antivenom serum in patients admitted to hospital after snake bite. DESIGN Prospective, double blind, randomised, placebo controlled trial. SETTING District general hospital in Sri Lanka. SUBJECTS 105 patients with signs of envenomation after snake b...