The articles in this Frontiers Research Topic describe how neurons integrate the signals carried by cyclic nucleotide. Three articles present original research, two papers provide provocative opinions about aspects of cyclic nucleotides signaling and four reviews provide timely summary and analysis of the state of the field. The three original articles illustrate how biosensors can reveal the d...

Making an informed decision with regards to a suitable business location or site selection for organizations is becoming challenging for business decision makers globally; and even more challenging in business environment that are saddled with uncertainties. The continues raise of multiple criteria variation of site preferences has also necessitated the application of advanced decision making t...

As a requirement for plant life extension more than 40 years some additional Aging Management Programs (AMP) passive equipment have to be implemented. The article presents overview of Cable Program (CAMP) implementation. defines basic rules and initial activities identification adverse operation environment parameters that could lead accelerated aging specific materials. Samples cables are sele...

Adenosine 3 ′, 5′-monophosphate (cAMP) is an important signaling molecule. CRP, the receptor protein of cAMP, acts as 'main' regulator for transcription factors. The CRP-cAMP complex directly controls at least 500 promoters in Escherichia coli. In this study, roles cyaA and crp genes E. coli BW25113 strain under metal stress were investigated. minimal inhibition concentration (MIC) cidal (MCC) ...

The article attempts to analyze the activities of forced labor camps using as an example functioning Forced Labor Camp Chuvash Autonomous Region (ChAO) in 1920–1921. work is based on previously unpublished sources State Historical Archive Republic. study shows features classifying prisoners, their number camp town Cheboksary, regime restrictions imposed them, it also analyses most frequent viol...

The American Chemical Society’s US National Chemistry Olympiad program has selected the 20 high school students that will attend 2023 Study Camp. camp take place from June 4 to 17 at University of Maryland, College Park. have already completed local and national chemistry olympiad exams. At camp, they be competing for a on four-member team representing 55th International Olympiad, held July 16–...

INTRODUCTION Rhodococcus equi is an opportunistic pathogen, causing rhodococcosis, a condition that can be confused with tuberculosis. Often, without identifying M. tuberculosis, physicians initiate empiric treatment for tuberculosis. R. equi and M. tuberculosis have different susceptibility to drugs. Identification of R. equi is based on a variety of phenotypic, chromatographic, and genotypic ...

Insulin-induced hypoglycemia previously has been shown to provoke a beta-adrenergic response that normally results in an increase in plasma renin activity (PRA). In our study, hypoglycemia induced definite increases in PRA in a group of five patients with normal renin essential hypertension but failed to do so in a group of six patients with low renin essential hypertension. In both groups, pla...