Gene therapy vectors are among the treatments currently used to treat malignant tumors. Gene therapy vectors use a specific therapeutic transgene that causes death in cancer cells. In early attempts at gene therapy, therapeutic transgenes were driven by non-specific vectors which induced toxicity to normal cells in addition to the cancer cells. Recently, novel cancer specific viral vectors have...

More than 90% of women with newly diagnosed breast cancer present stage I to III disease and, optimal multidisciplinary therapy, are likely survive their disease. Of these patients, 70% hormone receptor–positive and candidates for adjuvant endocrine therapy. The adoption cumulatively better treatments contributed improved outcomes in patients receptor–positive, early-stage cancer. Premenopausal...

objective: the number of new cancer cases with considerable mortality is increasing worldwide. since the inability of current therapies in treatment of patients and prevention the progress of tumors with fewer side effects, implementation of new methods is needed. gene therapy has widespread systemic cytotoxic effects against tumor cells. rotavirus nsp4 has been shown to elicit extensive cytoto...

background: the therapeutic administration of 131i for thyroid remnant ablation and for metastases comes up with some adverse effects. this study was conducted to investigate whether single high dose radioiodine therapy affects lacrimal gland functions or not. materials and methods: seventy-eight eyes of 39 patients, who were diagnosed as differentiated thyroid carcinoma, were objectively teste...

objectives: the aim of present study was examining the effectiveness of group metacognition treatment on metacognition beliefs in women with breast cancer. method: in a quasi-experimental design, with pre-test and post-test and control group, 24 patients with a diagnosis of breast cancer, among patients who referred to the division of oncology and  radiotherapy of  imam hossein hospital  in teh...

introduction: in patients with thyroid carcinoma, radiation absorbed doses of the thyroid and surrounding tissues is important to weigh risk and benefit considerations. in nuclear medicine, the accuracy of absorbed dose of internally distributed radionuclides is estimated by different methods such as mird and direct method using tld. the aim of this study is using tld and a phantom to determine...

dna vaccination has been developed as a noteworthy immunotherapeutic approach for the battle against many serious challenges to human and animal safety, including infectious illnesses, autoimmunity, allergy and cancer. clinical trials prepare chances to examine whether dna vaccines can fulfill their final aim of demonstrating efficiency in treating humans. today, anticancer dna vaccines are qui...

Uterine body cancer (UBC) makes up 7.1% of malignant tumors in women and ranks 6th the structure incidence world after breast cancer, cervical colorectal lung thyroid cancer. In developed countries, it is most common tumor female genital organs. The study included 105 patients with a diagnosis stage I uterine were divided into 2 groups: - main group consists 60 who received preoperative brachyt...

Gene therapy is an experimental treatment being investigated to correct defective genes that are responsible for disease development. To treat cancer and genetic illnesses, researchers looking into a variety of gene techniques. Finding proper vector transfer DNA tissues one the most difficult aspects therapy. Some vectors have issues with infecting both quiescent dividing cells, provoking immun...

BACKGROUND: Due to limitations of local and systemic therapies for prostate cancer, interest has continued in the development of new treatment modalities. Gene therapy has emerged as a new approach that may prevent or treat disease by using the therapeutic information encoded in DNA sequences. Several institutions are actively experimenting with this approach. METHODS: The authors review the mo...