We investigated the antifungal activities of itraconazole and voriconazole on Aspergillus species by time kill studies, and the results were compared with those obtained for Candida species. Exposure of Aspergillus fumigatus conidia to varying concentrations (1.25 to 10 microg/ml) of itraconazole and voriconazole resulted in cellular death; the cytocidal effect was time and concentration depend...

background: systemic candidiasis is a major complication in neutropenic cancer patients undergoing treatment. most systemic fungal infections emerge from endogenous microflora so the aim of the present study was to identify candida species isolated from the different regions of body   in neutropenic patients in compare with the control group. methods: a total of 309 neutropenic cancer patients ...

An essential factor to the virulence of the genus Candida is the ability to produce enzymes and this may be crucial in the establishment of fungal infections. Aim: This study investigated in vitro enzymatic activities of Candida species and their virulence in an in vivo Galleria mellonella experimental model. Methods: Twenty-four clinical strains of Candida spp. isolated from the human oral cav...

vulvovaginal candidiasis is caused by the increasing number of candida species as normal flora in the vagina. to assess the transmission rout as well as to determine the suitable antifungal drugs for treatment, the exact identification of candida species is crucial. therefore, earlier detection of infection allows quick initiation of antifungal therapy with a greater probability for improved su...

conclusions knowledge about the susceptibility patterns of colonized candida spp. can be helpful for clinicians to manage pediatric patients with neutropenia. in this study, caspofungin was the most effective antifungal agent against the colonized candida spp. followed by conventional amphotericin b. patients and methods in this study 188 children with neutropenia were recruited, fungal surveil...

background and aims. the clinical management of oral lichen planus poses considerable difficulties to the clinician. in recent years, researchers have focused on the presence of pathogenic microorganisms such as candida albicans in the patients with refractory lichen planus. the aim of the present study was to investigate the prevalence of candida species in the erosive oral lichen planus lesio...

vulvovaginal candidiasis (vvc) is a common disease among women worldwide, therefore, accurate and rapid diagnosis of causative agents based on molecular techniques utilizing amplification of target dna is highly recomendad for epidemiological purposes and for effective treatment. the aim of this study was to identify clinically candida species from vvc patients by restriction fragment length po...

INTRODUCTION Host colonization by Candida species is an important predisposing factor to candidiasis, which seems to be more frequent in human immunodeficiency virus (HIV)-infected patients. Knowledge about the distribution, antifungal susceptibility, and virulence of oral Candida isolates is important for effective management of candidiasis. METHODOLOGY Oral rinses were collected from 242 HI...

INTRODUCTION Urinary tract candidiasis is known as the most frequent nosocomial fungal infection worldwide. Candida albicans is the most common cause of nosocomial fungal urinary tract infections; however, a rapid change in the distribution of Candida species is undergoing. Simultaneously, the increase of urinary tract candidiasis has led to the appearance of antifungal resistant Candida specie...