OBJECTIVE The efficacy of topical natamycin 5% was studied using a reproducible model of keratomycosis produced by Candida albicans in the rabbits. METHOD Candida albicans was isolated from infected human eye and 4 x 10(5) cells of the Candida albicans was injected into the corneal stroma of the eyes of 15 rabbits. All eyes developed a corneal ulcer without pretreatment with immunosuppressive...

A clinical survey was carried out in seven cities in the southern part of Nigeria to determine the relative distribution of genitourinary Candida species in symptomatic patients reporting for diagnosis and treatment. Seven Candida species were identified using the CHROMagar Candida method and the API 20C System. Candida species were represented by Candida glabrata (33.7%), Candida albicans (20....

Onychomycosis is a fungal infection of nail, its matrix, and other nail parts which is usually caused by dermatophytes. However number of nail infections due to yeast and nondermatophyte moulds (NDM) is also increasing. Although Candida albicans accounts for most of the cases of onychomycosis caused by yeasts, there has been a change in the epidemiology of Candida infections, characterized by a...

Disruption of newly identified genes in the pathogen Candida albicans is a vital step in determination of gene function. Several gene disruption methods described previously employ long regions of homology flanking a selectable marker. Here, we describe disruption of C. albicans genes with PCR products that have 50 to 60 bp of homology to a genomic sequence on each end of a selectable marker. W...

Normal rabbit alveolar macrophages were infected in vitro with Candida albicans. Early after infection, germ tube formation of phagocytized C. albicans was inhibited in contrast to extracellular (nonphagocytized) C. albicans. Over and 8-h period, plate counts of C. albicans incubated with alveolar macrophages revealed a decrease in colony-forming units in contrast to C. albicans alone. In addit...

INTRODUCTION Worldwide, Candida albicans is the most common Candida species implicated in bloodstream infections. However, the proportion of non-albicans bloodstream infections is increasing. Fluconazole resistance is known to be more common in non-albicans species, but is also reported in C. albicans. This retrospective study was performed to determine the species epidemiology of Candida blood...

residual microorganisms in the root canal system (rcs) after endodontic therapy such as candida albicans are a major cause of endodontic failure. calcium hydroxide (ch) and chlorhexidine (chx) have suitable antimicrobial activity against bacteria and can be used as intracanal medicaments. nanosilver has also shown antimicrobial activity against microorganisms. this study aimed to compare the an...

conclusions totally, our results showed nanosilver caused an increase of at least nine-fold in inhibitory effect of fluconazole. materials and methods we studied effect of fluconazole, nanosilver, and their combination on 20 fluconazole-resistant c. albicans from two centers and one standard sample (atcc10261) by minimal inhibitory concentration (mic) method. background opportunistic fungi caus...