Abstract Zinc is one of the most important trace elements and deficiency can lead to significant clinical complications. Microbial transformation methods used supplement organic zinc there may be some naturally occurring microorganisms that have both higher tolerances capabilities. In this study, which displayed such characteristics were widely screened, a strain designated T-A was found. Morph...

Partial gyrB gene sequence analysis of 17 isolates from human and environmental sources revealed 13 clusters of strains and identified them as Burkholderia glathei clade (BGC) bacteria. The taxonomic status of these clusters was examined by whole-genome sequence analysis, determination of the G+C content, whole-cell fatty acid analysis and biochemical characterization. The whole-genome sequence...

Fenticonazole shows unique multimodal action against Candida species involving: 1. Inhibition of secretary aspartate protenase (SAP) there by preventing the growth, adherence, and penetration of Candida sp. including N-acetylcysteine leading to clinically significant reduction in the relapse rate (Figure 1). 2. Inhibits fungal cytochrome P450 3A enzyme, lanosine 14α-demethylase responsible for ...

Candida glycerinogenes WL2002-5 (C.g) is an important industrial strain for glycerol production. To further improve glycerol production, we reconstructed a binary vector pCAM3300-zeocin-CgGPD1, introduced it to Agrobacterium tumefaciens LBA4404 by electroporation, and then transformed the T-DNA harboring the CgGPD1 to Candida glycerinogenes by Agrobacterium tumefaciens-mediated transformation (...

The activity of a new, soluble and stable polyene (SPA-S-843) against Candida albicans was assessed by contact and culture tests and by inhibition of germ-tube formation. The drug demonstrated a higher contact activity and lower MICs than amphotericin B. This antimicrobial activity was more evident under acid pH and low ionic strength. In addition, the ability of SPA-S-843 to inhibit Candida sp...

objective: nowadays notable increase in acquired resistance of candida species to antifungal drugs and necessity of using agents with antifungal properties is unavoidable. in some plants due to presence of components such as polyphenols have antimicrobial properties. in this study antifungal effects of essential oils of thymus vulgaris, petroselinum crispum, cuminum cyminum and bunium persicum ...

Abilith of Candida spp to secrete extracellular enzymes and slime has been associated as pathogenicity factors. Out of a total of 37 strains of Candida sp, 100% were proteinase producers, 83.8% were phospholipase producers, 64.9% were slime producers and 100% were sensitive to fluconazole and itraconazole. Seventeen typings (enzymes/slime) were found. This methodology presented a good discrimin...