1. In experimental nephritis caused by cantharidin, arsenic, diphtheria toxin, and potassium chromate, in addition to the retention of the non-protein and urea nitrogen and of the chlorides in blood, an acidosis occurs. 2. Sodium bicarbonate given by the stomach has the power of diminishing the acidosis in these types of nephritis. 3. The degree of increase in the non-protein and urea nitrogen ...

Canthariphilous species are those arthropods attracted to cantharidin (CTD), a defensive compound produced by two beetle families (Meloidae and Oedemeridae). Although several known be CTD, canthariphily was recently discovered in new species, suggesting that the list of canthariphilous is still far from being complete. A systematic sampling focused detect has never been performed Italy. The pre...

BACKGROUND Cardiovascular disease occurs at lower incidence in premenopausal females compared with age-matched males. This variation may be linked to sex differences in inflammation. We prospectively investigated whether inflammation and components of the inflammatory response are altered in females compared with males. METHODS We performed 2 clinical studies in healthy volunteers. In 12 men ...

In this study we characterized the effects of the protein phosphatase (PP) type 1 and type 2A inhibitor cantharidin (Cant) and its structural analogs cantharidic acid and endothall on PP activity, force of contraction, and myosin light chain phosphorylation in rat aorta. All compounds inhibited PP activity in homogenates of rat aorta with a rank order of potency of Cant = cantharidic acid > end...