nary artery disease has provided an intense stimulus for expansion of our present knowledge of the coronary circulation. In the experimental animal laboratory, the electromagnetic flowmeter has proved to be an excellent tool by which one can study dynamic aspects of the coronary circulation. A flowmeter is clearly unsuitable for human investigation; therefore, the search for a simple method of ...

The changes in the coronary circulation, which are precipitated by the acute occlusion of the coronary sinus, have been investigated. In normal animals, retrograde blood emerging from the peripheral segment of a ligated and transected circumflex coronary artery is small in quantity, and arterial in nature, signifying an insignificant interarterial collateral flow. After the coronary sinus is ar...

The cerebral circulation has a central role in mediating the neurological complications of eclampsia, yet our understanding of how pregnancy and preeclampsia affect this circulation is severely limited. Here, we show that pregnancy causes outward remodeling of penetrating arterioles and increased capillary density in the brain due to activation of peroxisome proliferator-activated receptor-γ (P...

A 24 year old West Indian woman was admitted as an emergency having suffered an injury to the right knee on landing awkwardly on a trampoline. She was a reasonably experienced club trampoliner and on admission there was an obvious dislocation of the right knee joint. The peripheral pulses were absent in the right foot and capillary return was sluggish. The anterior dislocation (Figs. 1 and 2) w...

RENKIN, EUGENE M. Trans-ort of jwtassium-q2 from blood to pissue in isolated mammalian skeletal muscles. Am. J. Physiol. Ig7(6): no5-121o. I g5g.A method is described for studying transcapillary diffusion of K42 in isolated perfused muscles of dogs. Blood flow and arteriovenous K42 differences are mea+ ured and blood-tissue clearance calculated by the Fick principle. A theoretical relation betw...

This study of hemorrhagic shock syndrome in dogs evaluates commonly used therapeutic procedures on the basis of ability to correct specific vascular decompensatory episodes associated with progressive refractoriness to blood transfusion. Using specific criteria (vasomotion, responsiveness to vasoconstrictor stimuli, tone of arterioles and venules and capillary blood flow), it was found that pre...

This study of hemorrhagic shock syndrome in dogs evaluates commonly used therapeutic procedures on the basis of ability to correct specific vascular decompensatory episodes associated with progressive refractoriness to blood transfusion. Using specific criteria (vasomotion, responsiveness to vasoconstrictor stimuli, tone of arterioles and venules and capillary blood flow), it was found that pre...

The unique properties of brain capillary endothelium, critical in maintaining the blood-brain barrier (BBB) and restricting water permeability across the BBB, have important consequences on fluid hydrodynamics inside the BBB hereto inadequately recognized. Recent studies indicate that the mechanisms underlying brain water dynamics are distinct from systemic tissue water dynamics. Hydrostatic pr...

a capillary electrophoresis method was used for assay of some degradation products of carvedilol. the optimized parameters were as; running buffer 80 mm acetate dissolved in methanol/ethanol mixture (65:35 v/v), applied voltage of 19 kv, temperature is 20 ºc and the wavelength range of 200-350 nm. the results indicate that the proposed ce method could effectively separate carvedilol from its de...

deproteinisation with acetonitrile (along with methanol or other reagents) is a useful and rapid technique in analysis of drugs or their metabolites in human serum. in this paper application of this simple technique in biopharmaceutical analysis using capillary electrophoresis (ce) is evaluated. some drugs with different ionic and protein binding properties were selected and dissolved in human ...