Acinetobacter species are emerging as an important nosocomial pathogen. Multidrug-resistant Acinetobacter spp. has limited the option for effective treatment. Although carbapenems are effective for the treatment of such infections, resistance to this drug has recently been reported. This study was undertaken to assess resistance to carbapenem in clinical isolates of Acinetobacter spp. from hosp...

We recently reported a dramatic increase in the prevalence of carbapenem-resistant Acinetobacter baumannii infections in the intensive care unit (ICU) of a Vietnamese hospital. This upsurge was associated with a specific oxa23-positive clone that was identified by multilocus VNTR analysis. Here, we used whole-genome sequence analysis to dissect the emergence of carbapenem-resistant A. baumannii...

BACKGROUND There has been an increase in worldwide infections caused by carbapenem-resistant Acinetobacter. This poses a therapeutic challenge as few treatment options are available. OBJECTIVES The aim of this study was to evaluate the efficacy and safety of polymyxins and ampicillin/sulbactam for treating infections caused by carbapenem-resistant Acinetobacter spp. and to evaluate prognostic...

In the recent years, issues related to drug-resistant bacteria have evolved worldwide, and various countermeasures been taken control their spread. Among a wide variety of bacterial species, carbapenem-resistant Gram-negative bacteria, including Enterobacteriaceae (CRE) Acinetobacter baumannii (CRAb), are those for which particularly important. Carbapenems last resort antibiotics any infection;...

The ever-expanding role of extended-spectrum-β-lactamase (ESBL)-harboring and carbapenem-resistant Enterobacteriaceae in causing serious infections poses a grave public health threat because these organisms also tend to be multidrug resistant, for which very few (if any) antibiotic options remain available. Rapid detection of such panresistant organisms offers one of the best solutions to impro...

The emergence of Enterobacteriaceae strains resistant to both colistin and carbapenem, which harbor the mobile resistance (mcr) gene, has become a significant clinical public health concern. aim this study was identify with co-resistance carbapenem gain further understanding antimicrobial characteristics these in South Korea. Bacterial identification performed using MALDI Biotyper Vitek2 compac...

Background: The rates of postneurosurgical infections, particularly meningitis and the most common pathogens have been reported variable during the recent years. The aim of this research was to determine the prevalence of postneurosurgical meningitis and its current spectrum of infectious agent. Methods: In a descriptive study, the postneurosurgical patients’ cerebrospinal fluid was cultured o...

BACKGROUND Bacterial infections remain a challenge to solid organ transplantation. Due to the alarming spread of carbapenem-resistant gram negative bacteria, these organisms have been frequently recognized as cause of severe infections in solid organ transplant recipients. METHODS AND FINDINGS Between 15 May and 30 September 2012 we enrolled 887 solid organ transplant recipients in Italy with...

Carbapenems constitute a class of broad-spectrum antibiotics for the treatment of documented multidrug-resistant organisms and for use as empiric therapy in severe, life-threatening conditions,1,2 Hospital-acquired infections due to organisms such as Clostridium difficile and multidrug-resistant Pseudomonas aeruginosa are responsible for significant morbidity and mortality in the institutional ...