William E. Moen 1 September 1, 2000 DRAFT This chapter is forthcoming in Evaluating Networked Information Services: Techniques, Policy, and Issues edited by Charles R. McClure and John Carlo Bertot. Publisher: American Society for Information Science thru Information Today, Inc. Expected publication date, June 2001. DRAFT PREPRINT Assessing Interoperability in the Networked Environment: Standar...

BACKGROUND Fibroblasts are the main cells involved in regeneration during wound healing. The objective was to determine the effect of 940 nm diode laser on cultured human fibroblasts using different irradiation regimens. METHODS The CCD-1064Sk human epithelial fibroblast cell line was treated with a 940 nm diode laser at different energy doses (power: 0.2-1 W and energy density: 1-7 J/cm²) us...

BACKGROUND Acyclovir has pharmacokinetic limitations, including poor oral bioavailability of 15%-30%, high variability, and short elimination half-life of 2.3 hours. These limitations necessitate frequent administration of acyclovir, up to five times daily, leading to poor patient compliance, which in turn leads to a reduction in therapeutic efficacy and development of resistance. METHODS A g...

The current study involves development of oral bioadhesive hydrophilic matrices of hydralazine hydrochloride, and optimization of their in vitro drug release profile and ex vivo bioadhesion against porcine gastric mucosa. A 32 central composite design was employed to systematically optimize the drug delivery formulations containing two polymers, viz., carbomer and hydroxypropyl methyl cellulose...