This study describes the relationship between nitroglycerin, isosorbide dinitrate, sodium nitroprusside, and carbonic anhydrase I, as well as the involvement of this carbonic anhydrase I in vasodilation. Two groups of coronary patients and a group of rabbits underwent treatment with the above-mentioned vasodilating drugs. The activity of red blood cell carbonic anhydrase was monitored and deter...

We compare the effect of buffers on the catalysis by bovine carbonic anhydrase, human carbonic anhydrase C (HCA 0, and human carbonic anhydrase B (HCA B) of two types of ‘“0 exchange. Type I, resulting from the hydrationdehydration reaction, is the exchange of IsO between CO, and water. Type II is the exchange of IsO between ‘*Ccontaining and ‘“C-containing species of COZ. Imidazole, 2,4-lutidi...