The development of safe and energy efficient redox processes is key for a future sustainable organic chemistry storage/vector applications. Molecular electrocatalysts have demonstrated their potential in the realm CO2 reduction, however, successful implementations reduction other carbonyl groups remain sporadic. Building on reversibility hydrogenation dehydrogenation carbonyls alcohols, an over...

Hydrated carbonyl groups in AI-2, a quorum sensing autoinducer, make key hydrogen bonding interactions in the binding site of LsrR (a transcriptional regulator). This can be recapitulated with geminal dibromides, via halogen bonding. Geminal dihalogens represent interesting isosteric replacements for hydrated carbonyls in ligands and are currently under-utilized in ligand design.

Results: Supplementation of CoQ10 for thirteen weeks in adult animals resulted in decreased protein carbonyls due to oxidative posttranslational modifications in the plasma (approximately 21%) but an increase of the same in the brain tissue homogenate (approximately 21%) was observed. These alterations were statistically significant in the former while the increase in the latter was statistical...

A mild and general α-arylation of α-amino carbonyls with indoles catalyzed by Fe(ClO4)3 has been developed. C-H activation is smoothly fulfilled by using TBHP as the oxidant with good yields. Two hydrogen dissociations make this transformation more environmentally benign because of high atom efficiency.

During cold exposure, animals upregulate their metabolism and food intake, potentially exposing them to elevated reactive oxygen species (ROS) production and oxidative damage. We investigated whether acute cold (7 +/- 3 degrees C) exposure (1, 10, or 100 h duration) affected protein oxidation and proteasome activity, when compared to warm controls (22 +/- 3 degrees C), in a small mammal model, ...

OBJECTIVES This study investigated relationships between plasma myeloperoxidase (MPO), protein oxidation markers, and clinical outcome retrospectively in patients after acute myocardial infarction (MI). BACKGROUND Reactive oxidants are implicated in cardiovascular disease, and elevated plasma MPO is reported to predict adverse outcome in acute coronary syndromes. METHODS Detailed demographi...