Carboxyhaemoglobin (COHb) levels were studied in 11 249 men. The distribution among the 2613 men who smoked cigarettes was well separated from that in 6641 non-smokers (including ex-smokers). The distribution for 2005 cigar and pipe smokers was intermediate, though some of the highest COHb levels occurred in cigar smokers. Using a COHb cut-off level of 2%, 81% of cigarette smokers, 35% of cigar...

Exchange transfusion of large volumes of hemoglobin (Hb)-based oxygen carriers can protect the brain from middle cerebral artery occlusion (MCAO). Hb in the carboxy state (COHb) may provide protection at relatively low volumes by enhancing vasodilation. We determined whether transfusion of rats with 10 ml/kg PEGylated COHb [polyethylene glycol (PEG)-COHb] at 20 min of 2-h MCAO was more effectiv...

Lily, R. E. C., Cole, P. V., and Hawkins, L. H. (1972). Brit. J. industr. Med., 29, 454-457. Spectrophotometric measurement of carboxyhaemoglobin. An evaluation of the method of Commins and Lawther. The spectrophotometric method of Conmmins and Lawther for the measurement ofcarboxyhaemoglobin (COHb) concentration was evaluated for both accuracy and sensitivity. The method was calibrated by equi...

Lily, R. E. C., Cole, P. V., and Hawkins, L. H. (1972). Brit. J. industr. Med., 29, 454-457. Spectrophotometric measurement of carboxyhaemoglobin. An evaluation of the method of Commins and Lawther. The spectrophotometric method of Conmmins and Lawther for the measurement ofcarboxyhaemoglobin (COHb) concentration was evaluated for both accuracy and sensitivity. The method was calibrated by equi...

The purpose of this study is to use both agent-based modeling as a new method in modeling dynamic phenomena and GIS to show the effects of carbon monoxide (CO) on individuals in the city of Tehran. After collecting the latest information about the severity of carbon monoxide pollutants on different days, one of the days with a very high severity of this pollutant has been selected for investiga...

Background: Poisoning with carbon monoxide occurs occasionally worldwide, and the gold diagnostic standard is to measure carboxyhemoglobin level in the blood. This study investigated the correlation between carboxyhemoglobin and the end-tidal carbon dioxide levels in 50 patients with carbon monoxide poisoning. Methods: We recruited 50 volunteer patients who had been admitted to the Emergency S...

Carboxyhaemoglobin concentrations (COHb) have been measured in groups of individuals smoking while engaged in different activities. The three groups chosen (meat porters, office workers, and pregnant women) had finger-prick blood samples taken at about six hours into their working day. COHb was measured by the method of Commins and Lawther (1965), a method subsequently shown to have a mean erro...

AIMS To develop a population-based model to describe and predict the pharmacokinetics of carboxyhaemoglobin (COHb) in adult smokers. METHODS Data from smokers of different conventional cigarettes (CC) in three open-label, randomized studies were analysed using NONMEM (version V, Level 1.1). COHb concentrations were determined at baseline for two cigarettes [Federal Trade Commission (FTC) tar ...

An examination of carboxyhemoglobin levels in a community blood bank was undertaken to ascertain the human carboxyhemoglobin burden in relation to stored blood. Smoking histories were obtained from 198 volunteer blood donors. Carboxyhemoglobin determinations were made at the time of donation and at the time of recipient transfusion of the donor unit. T test for repeated measures demonstrated no...

BACKGROUND Chronic obstructive pulmonary disease and lung cancer are diseases associated with smoking tobacco cigarettes. Smokers find cessation difficult. OBJECTIVES To determine whether smoking the Twisp electronic cigarette (e-cigarette), containing nicotine in a vegetable-based glycerine substance, would reduce carboxyhaemoglobin (COHb) levels in regular cigarette smokers by (i) comparing...