Heterogeneity is one of the recognized characteristics of human tumors, and occurs on multiple levels in a wide range of tumors. A number of studies have focused on the heterogeneity found in primary tumors and related metastases with the consideration that the evaluation of metastatic rather than primary sites could be of clinical relevance. Nume...

A proliferating cell nuclear antigen (PCNA) was identified with autoantibodies from a patient with systemic lupus erythematosus. Specific antibodies were purified by affinity chromatography in which Novikoff hepatoma nucleolar proteins were conjugated to Sepharose-4B. The purified anti-PCNA antibodies produced bright nucleolar fluorescence in tumor cells as shown by indirect immunofluorescence....

Dear Editors: Adenocarcinoma of colon and rectum is the second most common cancer of the gastrointestinal (GI) tract in children. The development of carcinoma of colon in general appears to be associated with several predisposing factors such as familial polyposis, hereditary non-polyposis syndromes, ulcerative colitis, previous ureterosigmoidostomy or radiation therapy and dietary factors (hig...

tumor angiogenesis shown by microvessel count (mvc) or microvessel density (mvd), is assessed by several studies as prognostic factor in some types of tumors, and also in colorectal carcinoma. this article is payed to correlation between clincopathologic factors and tumor angiogenesis. in this study, immunohistochemical techniques are used for vascular evaluation in specimens from twenty-nine c...

MIDDLEKAMP, J.N. & HAFFNER, H. (1963) Carcinoma of the colon in children. Pediatrics, 32, 558. MORSON, B.C. & BUSSEY, H.J.R. (1970) Predisposing Causes of Intestinal Cancer-(monograph) Chicago, p. 31. Year Book Publishers, Inc. O'BRIEN, S.E. (1967) Carcinoma of the colon in childhood and adolescence. Canadian Medical Association Journal, 96, 1217. STALPORT, J. & LETAWE, P. (1971) Gardner's synd...

Understanding proteomic differences underlying the different phenotypic classes of colon and rectal carcinoma is important and may eventually lead to a better assessment of clinical behavior of these cancers. We here present a comprehensive description of the proteomic data obtained from 90 colon and rectal carcinomas previously subjected to genomic analysis by The Cancer Genome Atlas (TCGA). H...

Ameboma is a rare complication of amebic colitis presenting as a mass of granulation tissue with peripheral fibrosis and a core of inflammation related to amebic chronic infection. The initial presentations are usually obstruction and low gastrointestinal bleeding. The most common sites are the ascending colon and the cecum. It may mimic colon carcinoma, Crohn's disease, carcinoma of the colon,...