The sarcoplasmic reticulum Ca2'-ATPase (SERCA2) plays a critical role in the contractile performance of cardiac and slow-twitch skeletal muscle by restoring cytosolic calcium to low resting levels during the contractile cycle. We have previously shown that SERCA2 expression in the heart is altered by a number of pathophysiological stimuli. In an effort to define molecular mechanisms regulating ...

A new approach for investigating the mechanisms and evolution of cardiac muscle cell injury was presented by applying fine structural extracellular protein tracers in the catecholamine-induced cardiac muscle cell injury model. The results with these diffusion tracers indicated striking functional changes at the level of coronary microcirculation followed by early permeability alteration of card...

Protein kinase A (PKA)-dependent phosphorylation of troponin (Tn)I represents a major physiological mechanism during beta-adrenergic stimulation in myocardium for the reduction of myofibrillar Ca2+ sensitivity via weakening of the interaction with TnC. By taking advantage of thin filament reconstitution, we directly investigated whether or not PKA-dependent phosphorylation of cardiac TnI (cTnI)...

BACKGROUND Impaired skeletal muscle metabolism is recognized in chronic fatigue syndrome (CFS). This study examined the relationship between skeletal and cardiac muscle function and symptoms on standing in CFS using magnetic resonance spectroscopy (MRS) and impedance cardiography. MATERIALS AND METHODS Phosphocreatine (PCr)/adenosine triphosphate (ATP) ratio by cardiac MRS, PCr/ADP and proton...

Troponin complex Cardiac Muscle is a unique type of involuntary striated muscle which resembles skeletal muscle in many of its features. Cardiac muscle has several structural and functional di erences as compared to skeletal muscle. Structurally it is smaller, usually mononuclear, arranged more in series as opposed to parrallel, it has a greater number of mitochondria (cardiac muscle is almost ...

Meador BM, Krzyszton CP, Johnson RW, Huey KA. Effects of IL-10 and age on IL-6, IL-1 , and TNFresponses in mouse skeletal and cardiac muscle to an acute inflammatory insult. J Appl Physiol 104: 991–997, 2008. First published January 24, 2008; doi:10.1152/japplphysiol.01079.2007.—Exaggerated proinflammatory cytokine responses can be observed with aging, and reduced levels of the anti-inflammator...

Cardiac troponin T (cTnT) and troponin I (cTnI) are cardiac regulatory proteins that control the calcium mediated interaction between actin and myosin [1]. The troponin complex consists of three subunits: troponin C, troponin I, and troponin T. This complex is located on the myofibrillar thin (actin) filament of striated (skeletal and cardiac) muscle. The cardiac isoforms troponin T and I are o...

Cardiac muscle involvement is not a rare complication in muscle disorders as is most commonlyseen in muscular dystrophies. Hypertrophic and/or dilated cardiomyopathy progresses in parallel with disease progression in most of patients with Duchenne and Becker muscular dystrophies, though cardiac failure mayprecede skeletal muscle symptoms, especially in Becker form. Cardiac muscle involvement is...

Both pyruvate and lactate are extracted by the intact myocardium at physiological levels (1, 2) and are rapidly burned to CO2 in the intact cardiac muscle slice. They are interconverted by the diphosphopyridine nucleotide-dependent lactic acid dehydrogenase system and share a common final pathway for terminal oxidation (3, 4). Since these substrates are so closely related in carbohydrate metabo...

The origin of the term tissue engineering is not clear, but a 1985 proposal of Y.C. Fung to the National Science Foundation of the United States for a Center for the Engineering of Living Tissues and 2 conferences organized by the National Science Foundation in 1987 and 1988 are generally accepted as the origin of this lively and rapidly growing research field (The Emergence of Tissue Engineeri...