Cardiac resynchronization therapy (CRT) with biventricular pacing (BVP) is well-established in patients reduced left ventricular ejection fraction (LVEF), heart failure and wide QRS or indication for pacing. BVP achieves CRT through non-physiological fusion of paced wave-fronts from the RV endocardium LV epicardium. Conduction system utilizing bundle branch area has recently shown to be a safe ...

BACKGROUND Response to cardiac resynchronization therapy depends both on dyssynchrony and (regional) contractility. We hypothesized that septal deformation can be used to infer integrated information on dyssynchrony and regional contractility, and thereby predict cardiac resynchronization therapy response. METHODS AND RESULTS In 132 cardiac resynchronization therapy candidates with left bundl...

Milena A. Gebska, MD, PhD, Michael C. Giudici, MD, FHRS, James Rossen, MD, Jeffrey S. Wilson, MD, Gardar Sigurdsson, MD, Barry London, MD, PhD, Kanu Chatterjee, MB, FRCP (Lond), FRCP (Edin), MACP From the Division of Cardiovascular Diseases, University of Iowa, Iowa City, Iowa, Division of Cardiovascular Diseases Electrophysiology, University of Iowa, Iowa City, Iowa, and Division of Pulmonary ...

background: cardiac resynchronization therapy (crt) is an effective treatment for patients with moderate to severe heart failure. however, 20-30% of patients remain non-responders to crt. we sought to identify which patients benefit the most from crt in regard to the etiology of heart failure. methods: eighty-three consecutive patients (62 men) who had a biventricular pacemaker inserted at tehr...

Although many medical therapies are currently available for advanced cardiac dysfunction, there are fewer non-medical options. One of these options, Cardiac Resynchronization Therapy (CRT), targets the aberrant pattern of ventricular activation thereby reducing intra and interventricular asynchrony. Currently, heart failure patients with New York Heart Association class III or IV symptoms, a QR...