Randomized Evaluation of Carotid Occlusion and Neurocognition (RECON) trial: Main results Patients with carotid occlusion and hemodynamic failure had cognitive function measured before and after surgical vs medical intervention. Mild cognitive impairment at baseline improved over 2 years, but improvement did not depend on treatment group. There is a growing recognition that cerebral hemodynamic...

OBJECTIVE To elucidate the value of early computed tomographic (CT) signs of stroke in predicting the occlusion site in the cerebral arteries. PATIENTS 105 consecutive patients with acute embolic stroke affecting the anterior circulation. METHODS Four early signs were evaluated on cranial CT within six hours of stroke onset: loss of the insular ribbon (LIR); attenuation of the lentiform nuc...

201(5): 897-900. I g6 I .-Dogs under chloralose anesthesia show augmented reflex responses of systolic arterial pressure, mean arterial pressure, diastolic arterial pressure, and pulse rate to bilateral occlusion of the common carotid arteries over the responses of these same parameters before any a nesthesia. H yporeflexia, as indicated by these parameters, is observed when the anesthetic is c...

BACKGROUND Stroke associated with acute carotid occlusion is associated with poor effectiveness of tissue plasminogen activator (tPA) thrombolysis and poor prognosis. Rupture of atherosclerotic plaques resulting in vascular occlusions may occur on plaques, causing variable stenosis. We hypothesized that degree of stenosis may affect recanalization rates with tPA. Ultrasound+tPA (sonothrombolysi...

medications. Neurological examination revealed decerebrate rigidity and bilateral Babinski signs. CT on one day after admission demonstrated broad low-density area in the bilateral cerebral hemispheres, including the area of bilateral anterior cerebral artery and middle cerebral artery, but sparing the brainstem and occipital lobe (figure 1). Bilateral internal carotid artery embolisation was i...

BACKGROUND AND PURPOSE Stroke severity in cases of hyperacute carotid ischemic stroke may be related to site of arterial occlusion. We evaluated the relationships between National Institutes of Health Stroke Scale (NIHSS) scores and findings on intra-arterial digital subtraction angiograms (IA-DSA) of patients with ischemic stroke within 6 hr of stroke onset. METHODS A total of 43 consecutive...

Catatonic stupor is a condition characterized by generalised inhibition of motor activities where sensibilities are impaired and the individual has little or no appreciation of his surroundings. Fisher (1954) reported eight cases of carotid occlusion who presented initially as dementia. He concluded that the association of dementia and carotid occlusion in these cases may be entirely fortuitous...

BACKGROUND AND PURPOSE Evidence suggests that the protease-activated receptor-1 (PAR-1), a thrombin receptor, mediates neuronal injury in experimental cerebral ischemia. The present study investigated whether PAR-1 plays a role in brain injury after global cerebral ischemia. METHODS Adult male wild-type or PAR-1 knockout mice underwent a 20-minute bilateral common carotid artery occlusion or ...

BACKGROUND AND PURPOSE Prior to their relatively recent FDA approval, detachable balloons for endovascular arterial occlusion had been available on only a limited basis. We evaluated the feasibility of permanent endovascular carotid and vertebral artery occlusion using microcoils deployed with and without proximal flow arrest in 19 patients. METHODS Permanent endovascular occlusion was perfor...