grounds, implying the presence of senile plaques and neurofibrillary tangles in the hippocampus and cerebral cortex. Brain autopsy studies indicate that these lesions are present in about 90% of patients clinically diagnosed by experienced physicians. The utility of biomarkers for enhancing diagnositic sensitivity for AD may consequently be relatively limited since clinical methods are generall...

OBJECTIVES Oxidative stress and inflammation have been postulated as underlying mechanisms for the development of obesity-related insulin resistance. This association however, remains elusive especially in childhood. We sought to investigate this relation by measuring oxidative stress and antioxidant response biomarkers, before and during an oral glucose tolerance test (OGTT), in different biol...

To investigate the effects of carvacrol supplementation in rainbow trout induced by lipopolysaccharide (LPS), relative gene expressions levels of some pro-inflammatory cytokines and apoptosis markers in kidney and liver were measured. Fish with a mean weight of 44.71±1.33 g were studied using four different treatments with three replicates each. Inflammation and apoptosis were performed using L...

Chronic inflammation has long been recognized as a risk factor for many human cancers. One mechanistic link between inflammation and cancer involves the generation of nitric oxide, superoxide and other reactive oxygen and nitrogen species by macrophages and neutrophils that infiltrate sites of inflammation. Although pathologically high levels of these reactive species cause damage to biological...

CONTEXT Smoking is associated with increased fibrinogen and decreased paraoxonase (PON) activity, markers of inflammation and oxidative stress, in patients with coronary artery disease. OBJECTIVE We tested the hypothesis that the adverse effect of smoking on these biomarkers of inflammation and oxidative stress would be detectable in otherwise healthy young female habitual smokers. MATERIAL...

Ionizing radiation is undoubtedly the most frequently used means of cancer treatment especially in the case of solid tumors like breast, prostate etc. Significant evidence suggests that long-term effects of radiation in patients who have undergone even successful treatment include high oxidative stress and inflammation in their blood and various tissues and the underestimation of the so called ...

OBJECTIVE To investigate the comparative acute health effects associated with exposures to diesel and 75% biodiesel/25% diesel (B75) blend fuel emissions. METHODS We analyzed multiple health endpoints in 48 healthy adults before and after exposures to diesel and B75 emissions in an underground mine setting-lung function, lung and systemic inflammation, novel biomarkers of exposure, and oxidat...

BACKGROUND Mechanisms involving oxidative stress and inflammation have been proposed to explain associations of ambient air pollution with cardiovascular morbidity and mortality. Experimental evidence suggests that organic components and ultrafine particles (UFP) are important. METHODS We conducted a panel study of 60 elderly subjects with coronary artery disease living in retirement communit...

Transcriptome alterations in liver and adipose tissue of cows with subclinical endometritis (SCE) at 29 d postpartum were evaluated. Bioinformatics analysis was performed using the Dynamic Impact Approach by means of KEGG and DAVID databases. Milk production, blood metabolites (non-esterified fatty acids, magnesium), and disease biomarkers (albumin, aspartate aminotransferase) did not differ gr...