Several concepts have been used to describe potential serous accidents in industrial activities. Examples of these concepts are worst case scenarios, likelier-but-less-catastrophic scenarios, most credible scenarios etc. A worst case scenario is a sequence of events/actions/accidents for a certain place (site) and time which causes the worst magnitude of an accident. Often these kind of acciden...

Our era is undoubtedly the era of “big data.” This digitized data is everywhere,but in thepracticeof arthroplastysurgery thisera ismost evident in how we commonly learn about surgical outcomes e joint registries, administrative databases, the Centers for Medicare and Medicaid Services’ Hospital Compare website. By collating or sampling “big data,” the potential bias of anecdotal results is dilu...

Literature reports of suspected adverse drug reactions (ADRs) associated with medicinal products for human use are not just an integral part of signal detection activities, but are also an important source of information for professionals involved in patient management. Therefore, it is with great pleasure that Adis (Springer) announces the launch of Drug Safety Case Reports, a new peerreviewed...

We report a case of a 75-year-old female with bilateral thigh pain for several years secondary to soft tissue calcification. Massive calcinosis of the soft tissues is a unique, but not uncommon, radiographic finding. On the contrary, tumoral calcinosis is a rare familial disease. The term tumoral calcinosis has been overly used to describe any massive collection of periarticular calcification. ...

The case report by Brander and colleagues diaphragm weakness due to one of the many causes listed by Brander and colleagues remain of severe diaphragm weakness due to phrenic nerve damage from radiotherapy given many undiagnosed despite diaphragm dysfunction contributing to symptoms of breathlessness and years earlier is of considerable interest. 1 It provides yet another cause of diaphragm dys...

We carried out a systematic review of HPV vaccine pre- and post-licensure trials to assess the evidence of their effectiveness and safety. We find that HPV vaccine clinical trials design, and data interpretation of both efficacy and safety outcomes, were largely inadequate. Additionally, we note evidence of selective reporting of results from clinical trials (i.e., exclusion of vaccine efficacy...

Medicine is built up of single cases. Individual patients-single cases-are the essence of what medicine deals with. Every patient is important, and every case can be a lesson. Clinician, researcher, and epidemiologist Alvan Feinstein said, "In caring for patients, clinicians constantly perform experiments. During a single week of active practice, a busy clinician conducts more experiments than ...

Pseudomyxoma peritonei is a relatively rare and poorly understood condition in which mucus accumulates within the peritoneal cavity. The presence of cells in the mucin, either inflammatory or neoplastic, distinguishes it from simple acellular mucus ascites caused by mucinous spillage. There is widespread seeding of the peritoneal and omental surfaces with a heavy cancerous glaze. This is princi...