Variability in DNA repair capability may be a determinant of interindividual difference in susceptibility to carcinogenic exposures. A cytogenetic assay which quantifies chromosomal breakage induced by in vitro exposure to a clastogen provides an indirect measure of repair. We report the results of a casecontrol study of upper aerodigestive trad cancers assessing differences in mutagen sensitiv...

The relation has not been reported consistently between the polymorphisms in the gene of apolipoprotein A5 (APO A5) and coronary artery disease (CAD). To clarify the discrepancy, we conducted a comprehensive search of PubMed and EMBASE for all available casecontrol studies to explore the association between two APO A5 polymorphisms and CAD. Two reviewers independently selected studies. Statisti...

Target: The objective of this study was to investigate the association of paraoxonase 2 (PON2) Ala148Gly (A148G) and Ser311Cys (S311C) polymorphisms with the susceptibility to preterm birth. Methods: In this casecontrol study, we genotyped PON2 A148G and S311C polymorphisms of 110 premature infants and 121 normal infants using polymerase chain reaction-restriction fragment length polymorphism (...

Familial aggregation of Waldenström macroglobulinemia (WM) and related B-cell disorders (BCDs) suggests a role for genetic factors, but few data address environmental influences. We designed a questionnaire-based study to examine clinical and environmental factors in a cohort of WM families with various patterns of case aggregation. We analyzed data on 103 WM patients and 272 unaffected relativ...

The role of mitochondrial DNA (mtDNA) variant 16189T>C in type 2 diabetes mellitus (T2DM) remains hotly debated in the past decade. If mutation 16189T>C indeed posed a risk to T2DM, as echoed by some recent studies, correlation between this mutation and disease should be observed when carrying out a systematical study using data and samples collected in a large geographic region in China. To te...

oping multiple sclerosis: evidence from a migrant population in Australia. Brain 2000;123:968-74. 9 Hammond SR, McLeod JG, Millingen KS, Stewart-Wynne EG, English D, Holland JT, et al. The epidemiology of multiple sclerosis in three Australian cities: Perth, Newcastle and Hobart. Brain 1988;111:1-25. 10 Jones G, Blizzard C, Riley MD, Parameswaran V, Greenaway TM, Dwyer T. Vitamin D levels in pr...

There has been an explosion in the incidence of breast cancer throughout the world. A casecontrol study was done to identify the lifestyle risk factors for breast cancer among women in Klang Valley. This study was carried out among 70 newly diagnosed breast cancer patients and 138 controls, aged 29-65 years old in Klang Valley. The inclusion criteria for cases were (i) newly diagnosed breast ca...

Background: Our previous study showed that the protective effect of Bacillus Calmette-Guerin (BCG) declined with time, which is supported by a following study saying "BCG vaccination protection against tuberculosis varies between populations, to an extent that cannot be attributed to chance alone". Objective: To investigate BCG protective effect among Chinese people, so as to update the develop...

Asthmatic patients with nasal polyposis (NP) have been reported to have a high prevalence of bronchial hyperresponsiveness (BHR) and a worsening of quality of life (QoL). The aim of this casecontrol study was to evaluate if NP is a determinant of BHR and is responsible for modifying the QoL in asthmatic subjects. Eighty-nine asthmatic subjects, including 24 patients with NP and 65 patients with...

Introduction Connection of socioeconomic status measures (such as income and education and parental addiction) to childhood leukemia are likely to vary with place and time. The aim of this study was to assess the relation between socioeconomic status and childhood leukemia. Materials and Methods a casecontrol study conducted on 86 case of acute lymphoblastic leukemia age 0-14 years in Shahid Sa...