نتایج جستجو برای: casp8
تعداد نتایج: 645 فیلتر نتایج به سال:
We describe predictions made using the Rosetta structure prediction methodology for the Eighth Critical Assessment of Techniques for Protein Structure Prediction. Aggressive sampling and all-atom refinement were carried out for nearly all targets. A combination of alignment methodologies was used to generate starting models from a range of templates, and the models were then subjected to Rosett...
The prediction of the 3-dimensional structure of a protein given its chemical composition (that is, its amino acid sequence), remains an elusive problem in spite of decades of research efforts. The rate of progress in the field is even stagnating, and much of the improvements seen in the last couple of years can be attributed to larger databases of experimentally determined protein structures, ...
A CASH injection to boost midwifery services throughout England will improve facilities but may not ease staffing crises, midwives fear.
Epigallocatechin-3-gallate (EGCG) is the major bioactive component of green tea. Our experimental data indicated that EGCG treatment suppresses cell proliferation of SSC-4 human oral squamous cell carcinoma (OSCC), the effect being dose- and time-dependent. In parallel was observed the activation of apoptosis and autophagy, in response to EGCG exposure in SSC-4 cells. Treatment with EGCG activa...
DNA methylation is recognized as the most important epigenetic change in the malignant transformation. It includes global hypermethylation and the hypermethylation of CpG islands localized in the regulatory regions of most human genes [1, 2]. Methylated cytosine may undergo spontaneous deamination, producing a C → T transition, which, if in the promoter, may significantly affect the level of ex...
RESEARCH DESIGN AND METHODSdThe expression levels of initiator (CASP8/9) and effector (CASP3/7) caspases as well as antiapoptotic B-cell lymphoma (BCL)2 and inflammatory markers were assessed in visceral (VAT) and subcutaneous (SAT) adipose tissue from patients with different degrees of obesity and without insulin resistance or diabetes. Adipose tissue explants from lean subjects were cultured ...
The other 90% of the protein: Assessment beyond the Cas for CASP8 template-based and high-accuracy models Daniel A. Keedy, Christopher J. Williams, Jeffrey J. Headd, W. Bryan Arendall III, Vincent B. Chen, Gary J. Kapral, Robert A. Gillespie, Jeremy N. Block, Adam Zemla, David C. Richardson, and Jane S. Richardson* 1Department of Biochemistry, Duke University Medical Center, Durham, North Carol...
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