Inbred AxC strain male and female rats were fed 0.025% 7V-2-fluorenyldiacetamide in the diet. Growth hormone was administered to intact and castrated animals to determine its effect on carcinogenesis and cirrhosis of the liver. Growth hormone increased the incidence of hyperplastic and neoplastic lesions and cirrhosis in both castrated males and castrated females, but it did not exert any effec...

Introduction Cancer has been associated with increased oxidative stress and deregulation of bioactive oxylipins derived from long-chain polyunsaturated fatty acids (LC-PUFA) like arachidonic acid (AA). There is a debate whether ω-3 LC-PUFA could promote or prevent prostate tumor growth through immune modulation reduction stress. Our aim was to study the association between enzymatically non-enz...

Welfare concerns are growing regarding surgical castration (SC) in pets, necessitating the need for non-surgical alternatives. Administration of vaccines against gonadotropins releasing hormone (GnRH) have been reported as alternative to SC. This study determined the effect of surgical and immunological castrations (IC) on complete blood counts, plasma testosterone (T), luteinizing hormone (LH)...

BACKGROUND AND PURPOSE A number of studies indicate that the female gonadal hormone, estrogen, confers protection against cerebrovascular disorders such as stroke. One postulated mechanism for these effects of estrogen is an action on the enzyme endothelial nitric oxide synthase (eNOS), which produces the vasodilatory molecule NO. We have investigated the hypothesis that estrogen increases expr...

Gametocyte sex ratio of the malaria parasite Plasmodium mexicanum is variable in its host, the western fence lizard (Sceloporus occidentalis), both among infections and within infections over time. We sought to determine the effect of host physiological quality on the gametocyte sex ratio in experimentally induced infections of P. mexicanum. Adult male lizards were assigned to 4 treatment group...

The morphology of the rat lung was studied by light microscopy in different situations: after surgical and pharmacological castration and after administration of testosterone to the castrated rat to determine if the androgen is required to maintain the normal morphology of the lung. We also determined the effect of flutamide on the phospholipid composition of both the surfactant and microsomes ...

A man's male hormones may ward off heart damage by helping vessels around the heart regenerate, suggest Sieveking and colleagues. Although studies have shown that estrogen helps regenerate blood vessels, both in the uterus after menstruation and around the heart after wear and tear, little is known about whether or not men make up for a lack of the female hormone. Some researchers have theorize...

© Translational Andrology and Urology. All rights reserved. Transl Androl Urol, 2015;4(S1) www.amepc.org/tau castrated rats than in controls, and testosterone restored these decreases (each P<0.05). The expression levels of cyclooxygenase-2 (COX-2), prostacyclin synthase (PTGIS or PGIS), endothelial nitric oxide synthase (eNOS) and phospho-eNOS were reduced in castrated rats compared with contr...

The paper reports a 5 year old male sheep-goat interspecific hybrid born under natural conditions. The hybrid was castrated at 10 months of age. Karyotype analysis confirmed that the animal was a male and a hybrid with 57 chromosomes, an intermediate number between sheep (2n=54) and goat (2n=60). Morphological characteristics of the animal were compared with those of castrated male Tswana goats...