نتایج جستجو برای: cationic amino acid transporter 2
تعداد نتایج: 3164682 فیلتر نتایج به سال:
The phosphoinositide-dependent kinase PDK1 activates the serum- and glucocorticoid-inducible kinase isoforms SGK1, SGK2, and SGK3 and protein kinase B, which in turn are known to up-regulate a variety of sodium-coupled transporters. The present study was performed to explore the role of PDK1 in amino acid transport. As mice completely lacking functional PDK1 are not viable, mice expressing 10-2...
Amino acid transport systems mediating uptake of nitric oxide (NO) synthase inhibitors were characterized in the murine macrophage cell line J774. Treatment of J774 cells with bacterial endotoxin (LPS, 1 microgram ml-1, 24 h) selectively increased the transport capacity for NG-monomethyl-L-[14C]arginine (L-NMMA), whereas transport of NG-nitro-L-[3H]arginine (L-NNA) was unaffected. Inhibition st...
Antimicrobial peptides (AMPs) have been an area of great interest, due to the high selectivity of these molecules toward bacterial targets over host cells and the limited development of bacterial resistance to these molecules throughout evolution. The peptide C18G has been shown to be a selective, broad spectrum AMP with a net +8 cationic charge from seven lysine residues in the sequence. In th...
Changes in placental nutrient transport are closely associated with abnormal fetal growth. However, the molecular mechanisms underlying the regulation of placental amino acid transporters are unknown. We demonstrate that physiological concentrations of the proinflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha stimulate the activity of amino acid transporter system A...
the binding of sodium n-dodecyl sulphate (sds) to aspergillus niger catalase in various ionic strengths at ph 6.4 and a temperature of 27? and 37?c has been studied over a range of sds concentrations using equilibrium dialysis and fluorescence spectroscopy techniques. the binding data were used and interpreted in terms of theoretical models (scatchard equation and wyman binding potential). the ...
Mahendra Singh Rathore B R Nahata College of Pharmacy, (Affiliated to Rajiv Gandhi Prodhyogiki Vishwavidhylalaya, Bhopal, MP) P B 06, Mhow Neemuch Road, Mandsaur, MP 458001 India Email: [email protected] Abstract In last few years transporter targeted drug delivery has drawn attention of research to identify and explore various nutrient transport systems including amino acid transporter...
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