In this paper, we establishes certain new weighted Young and P?lya-Szeg?-type inequalities involving Marichev-Saigo-Maeda fractional integral operators. Meanwhile, corresponding Cauchy-Schwarz type inequalities, Shisha-Mond Diaz-Metcalf for operators are also obtained. As applications, some estimates Chebyshev-type with two unknown functions presented. The main results of paper more general inc...