نتایج جستجو برای: cccp
تعداد نتایج: 498 فیلتر نتایج به سال:
زمینه و هدف: یکی از مهمترین مکانیسمهای مقاومت به کینولونها در اشرشیاکلی، فعالیت پمپ ترشحی AcrAB است. در این مطالعه فراوانی ژنهای acrA، acrB و اثر پمپ برونریز برروی مقاومت به سیپروفلوکساسین در جدایههای اشرشیاکلی مولد بتالاکتامازهای طیف گسترده (ESBL) بررسی گردید. روش بررسی: این مطالعه تجربی بر روی ۶۶ نمونه اشرشیاکلی مولد ESBL جداشده از نمونه ادرار بیماران سرپایی مراجعهکننده به 2 مرکز پزشکی...
Background and Objective: One of the mechanisms involved in the resistance of Klebsiella pneumoniae to fluoroquinolones is AcrAB leakage pumps. In this study, the prevalence of Klebsiella pneumoniae isolates with AcrAB encoding genes and the role of permeation pumps in fluoroquinolone resistance were investigated. Materials and Methods: 165 samples from patients of Kermanshah Medical Centers ...
Context. Supernova (SN) 1987A was a peculiar hydrogen-rich event with a long-rising (∼ 84 d) light curve, stemming from the explosion of a compact blue supergiant star. Only a few similar events have been presented in the literature in recent decades. Aims. We present new data for a sample of six long-rising Type II SNe (SNe II), three of which were discovered and observed by the Palomar Transi...
OBJECTIVES The aim of this study was to characterize the efflux pump Tap from Mycobacterium fortuitum, to test its sensitivity to well known efflux inhibitors, to study the interaction between tetracycline and these compounds and to test the ability of these compounds to overcome efflux pump-mediated tetracycline resistance. For all these studies, we produced Tap protein in Mycobacterium smegma...
In isolated single cardiomyocytes with moderately elevated mitochondrial respiration, direct evidence for intracellular radial gradients of oxygen concentration was obtained by subcellular spectrophotometry of myoglobin (Mb). When oxygen consumption was increased by carbonyl cyanide m-chlorophenylhydrazone (CCCP) during superfusion of cells with 4% oxygen, PO(2) at the cell core dropped to 2.3 ...
Synaptic vesicles isolated from sheep brain cortex exhibit an ATP-dependent Ca2+ accumulation that is inhibited by the protonophore uncoupler carbonyl cyanide m-chorophenylhydrazone (CCCP) and completely released by the Ca2+ ionophore ionomycin. This transport activity was sensitive to the V-type ATPase inhibitor, bafilomycin, but not to the P-type ATPase inhibitor, vanadate. We also observed t...
Protonophorous uncouplers causing a partial decrease in mitochondrial membrane potential are promising candidates for therapeutic applications. Here we showed that hydrophobic penetrating cations specifically targeted to mitochondria in a membrane potential-driven fashion increased proton-translocating activity of the anionic uncouplers 2,4-dinitrophenol (DNP) and carbonylcyanide-p-trifluorophe...
Differentiation-inducing factor-3 (DIF-3), found in the cellular slime mold Dictyostelium discoideum, and its derivatives such as butoxy-DIF-3 (Bu-DIF-3) are potent anti-tumor agents. However, the precise mechanisms underlying the actions of DIF-3 remain to be elucidated. In this study, we synthesized a green fluorescent derivative of DIF-3, BODIPY-DIF-3, and a control fluorescent compound, Bu-...
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