In this study, we investigated whether CD4+CD25high regulatory T cells (Treg) are increased in the tumor tissue and peripheral blood of early-stage prostate cancer patients undergoing prostatectomy. We show that the prevalence of CD4+CD25high T cells inside the prostate was significantly higher in the tumor compared with benign tissue from the same prostate. Furthermore, the frequency of CD4+CD...

T-cells undergo polyclonal expansion in cutaneous psoriasis (PsC) and PsA, with persistence of “driver clones” after effective treatment (JCI 127:4031; JI 172:1935). A recent scRNA-seq study found roughly equal compartments clonal non-clonal Th17 Tc17 cells PsC (Science 371:364). We others have shown that from PBMC requires contact between monocytes memory the context TCR ligation (PNAS 104:170...

Multiple sclerosis (MS) is an autoimmune disease that affects the CNS. One approved treatment for relapsing forms of MS is YEAK, a random copolymer of the amino acids tyrosine, glutamic acid, alanine, and lysine. YFAK, a second-generation copolymer composed of tyrosine, phenylalanine, alanine, and lysine, is more successful in treating experimental autoimmune encephalomyelitis, a mouse model of...