نتایج جستجو برای: ccr2b receptor inhibitors
تعداد نتایج: 746644 فیلتر نتایج به سال:
Thiol-mediated uptake is emerging as method of choice to penetrate cells. This study focuses on irreversible covalent inhibitors thiol-mediated uptake. High-content high-throughput screening the so far largest collection hypervalent iodine reagents affords that are more than 250 times active Ellman’s reagent and rival best dynamic inhibitors. Comparison with other reveals inhibition within one ...
The skin forms an interface between the body and environment provides distinct niches for microbial communities. Next-generation-sequencing used to characterize cutaneous microbiome in psoriasis patients revealed over-representation of Proteobacteria a reduction Actinobacteria lesional skin, suggesting that development psoriatic plaques might be linked specific alterations successful treatment ...
Although most prostate cancers are localized, and the majority curable, recurrences occur in approximately 35% of men. Among patients with prostate-specific antigen (PSA) recurrence PSA doubling time (PSADT) less than 15 months after radical prostatectomy, cancer accounted for 90% deaths by years recurrence. An immunosuppressive tumor microenvironment (TME) impaired cellular immunity likely lar...
Difficult to detect, ovarian cancer typically presents at an advanced stage. Significant progress has been achieved in the treatment of ovarian cancer with therapeutics focused on DNA replication or cell division. However, despite sensitivity to induction chemotherapy the majority of patients will develop recurrent disease. Conventional agents for recurrent disease offer little in terms of long...
Objective: In this study, it was aimed to carry out computational studies for the development of new molecules inhibition cyclophilin D (CypD) receptor, which causes disability mitochondrial function in multiple sclerosis (MS) disease. Material and Method: Pharmacophore modeling study applied via PharmaGist Web server CypD inhibitors detected by literature search. According best pharmacophore m...
Cetuximab is a powerful anti-neoplastic agent that can inhibit cell growth in oral squamous carcinomas (OSCCs). Unfortunately, there are cases with unfavorable outcomes. Because few studies have focused on the combined effects of cetuximab and histone deacetylase (HDAC) inhibitors, we aimed to evaluate antitumor effect combination HDAC inhibitors human OSCC lines, investigate mechanism apoptosi...
BACKGROUND The effect on cardiovascular outcomes of withholding angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers in chronic users before noncardiac surgery is unknown. METHODS In this international prospective cohort study, the authors analyzed data from 14,687 patients (including 4,802 angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker users) ...
Background Arterial stiffness and hypertension are strong predictors of cardiovascular disease mortality. Angiotensin-converting enzyme inhibitors (ACEI) angiotensin receptor blockers (ARB) first-line antihypertensive agents in reducing blood pressure arterial stiffness. Objective The objective this study was to compare the effects ACEI ARB preventing target organ damage patients with hypertens...
Mammalian secreted phospholipases A(2) (sPLA(2)s) constitute a family of structurally related enzymes that are likely to play numerous biological roles because of their phospholipid hydrolyzing activity and binding to soluble and membrane-bound proteins, including the M-type receptor. Over the past decade, a number of competitive inhibitors have been developed against the inflammatory-type huma...
This review article outlines the current development of emerging treatment strategies for primary central nervous system lymphoma, a rare brain tumor with, thus far, limited therapeutic options. Small molecule targeted tyrosine kinase inhibitors, immunomodulatory agents, and immune checkpoint inhibitors will be discussed. The mechanisms action, results completed clinical studies, ongoing trials...
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