We sought to determine the cartilage repair capacity of WIN-34B in the collagenase-induced osteoarthritis rabbit model and in progenitor cells from subchondral bone. The cartilage protective effect of WIN-34B was measured by clinical and histological scores, cartilage area, and proteoglycan and collagen contents in the collagenase-induced osteoarthritis rabbit model. The efficacy of chondrogeni...

Objective: The aim of the present study was to evaluate the Microvessel density(MVD) recognized by Endoglin (CD105) expression in invasive ductal carcinomas (IDC) and precancerous lesions patients including ductal carcinoma in situ(DCIS) and atypical ductal hyperplasia(ADH), as well as to analyze the relationship between the MVD recognized by Endoglin expression with other stan prognostic param...

OBJECTIVES Although several studies have been conducted regarding Kaposi sarcoma (KS), its histogenesis still remains to be elucidated. The aim of our study was to analyze the immunophenotype of Kaposi sarcoma and to present a hypothesis about the histogenesis of this tumor, based on a case series and a review of relevant literature. METHODS In 15 cases of KSs diagnosed during 2000-2011, the ...

AIMS To evaluate the prognostic impact of tumour angiogenesis assessed by vascular endothelial growth factor (VEGF), microvessel density (MVD), and tumour vessel invasion in patients who had undergone radical resection for stage IB-IIA non-small cell lung cancer (NSCLC). METHODS Fifty one patients (42 men, nine women; mean age, 62.3 years; SD, 6.9) undergoing complete surgical resection (35 l...

Angiopoietin (Ang)-1 and -2 have been recently identified as potent angiogenic factors which function in concert with vascular endothelial growth factor (VEGF), but no detailed clinical study on Ang expression has been reported. To assess the clinical significance of Ang expression in non-small cell lung cancer (NSCLC), a total of 236 patients with pathological stage-I-IIIA disease were retrosp...

In this work, we recruited CD105 and CD90 markers to identify the endometrial stem cells (EnSCs) in human uterine endometrium. Fifty specimens have been extracted from twenty-five deceased women. All embedded paraffin block prepared for immune-histochemical processing. The expression of was counted per high power field (HPF). Paired sample t-test used compare means between groups age variables....

Human Mesenchymal Stem Cells (hMSCs) present a promising tool for regenerative medicine. However, ex vivo expansion is necessary to obtain sufficient cells for clinical therapy. Conventional growth media usually contain the critical component fetal bovine serum. For clinical use, chemically defined media will be required. In this study, the capability of two commercial, chemically defined, seru...