Abstract INTRODUCTION Glioblastoma (GBM) is the most malignant brain tumor in adults, with a dismal prognosis despite aggressive therapy. Immunotherapy currently being evaluated as treatment modality for recurrent GBM. MRI not adequate response assessment to immunotherapy even after using refined criteria. Thus, there need development of neuroimaging techniques assessment. T-cells are key media...

PURPOSE To assess the effects of mycophenolate mofetil (MMF) therapy on T helper cell activation status, using CD69 expression and cytokine profile with flow cytometry in relation to clinical activity in uveitis. METHODS Patients with posterior or intermediate uveitis treated with MMF (n = 10), patients with active uveitis not treated with MMF and receiving no or minimal therapy (n = 10), and...

Objective To clarify if NK and NKT cells are activated via complement in NMOSD. Background Inhibition of terminal NMOSD using eculizumab has been shown to be helpful preventing relapses but exactly how the drug is working not clear. Similarly, genetic variants Fc Gamma receptor 3A correlated with outcomes immune expressing those FcGR3A receptors unknown. We compared expression on modulated by a...

We analyzed the interaction between human peripheral blood natural killer (NK) cells and monocyte-derived immature dendritic cells (DC). Fresh NK cells were activated, as indicated by the induced expression of the CD69 antigen, and their cytolytic activity was strongly augmented by contact with lipopolysaccharide (LPS)-treated mature DC, or with immature DC in the presence of the maturation sti...

Catumaxomab (CatmAb), a trifunctional bispecific antibody directed against the epithelial cell adhesion molecule (EpCAM) and the T-cell antigen CD3, is approved as intraperitoneal therapy for the treatment of malignant ascites in patients with EpCAM-positive carcinomas. The immunomonitoring results of a phase II/III study using CatmAb revealed a tumoricidal effect associated with reduced VEGF l...

The murine gammaherpesvirus MHV-68 multiplies in the respiratory epithelium after intranasal inoculation, then spreads to infect B cells in lymphoid germinal centers. Exposing B cells to MHV-68 in vitro caused an increase in cell size, up-regulation of the CD69 activation marker, and immunoglobulin M (IgM) production. The infectious process in vivo was also associated with increased CD69 expres...

PURPOSE To investigate the frequency and phenotypic and functional characteristics of S-antigen (S-Ag) specific T cells in patients with Behcet's disease (BD). METHODS Blood was taken from 23 active BD patients, 12 inactive BD patients, and 14 healthy controls. The clinical features of the patients were summarized. T cell response against 40 mixed S-Ag peptides was identified by interferon ga...

Numerous clinical and epidemiological studies link enteroviruses such as the Coxsackie virus group with the autoimmune disease type 1 diabetes mellitus (DM). In addition, there are reports that patients with type 1 DM are characterized by skewing of TCR Vbeta chain selection among peripheral blood and intraislet T lymphocytes. To examine these issues, we analyzed TCR Vbeta chain-specific up-reg...

Chimeric-antigen-receptor (CAR) T-cell therapy for CD19-expressing B-cell malignancies is already widely adopted in clinical practice. On the other hand, development of CAR-T-cell its nascent stage. One potential targets CD26, to which we have developed and evaluated efficacy safety humanized monoclonal antibody YS110. We generated second (CD28) third (CD28/4-1BB) generation CD26-targeted CAR-T...

Abstract ROS are small short-lived oxygen-containing molecules which highly chemically reactive and involved in the regulation of biological processes like T cell activation proliferation. The tumor microenvironment (TME) is a metabolically hostile environment with deficiency nutrients glucose glutamine, accumulation tumor-driven metabolic waste, extreme hypoxia. Hypoxia results impaired mitoch...