Introduction: Orelabrutinib (O), as a novel highly selective bruton tyrosine kinase inhibitors (BTKi), preserved NK-cell-mediated antibody-dependent cellular cytotoxicity (ADCC) induced by rituximab (R) and thus boost antitumor effect of R-based regimen. We aimed to analyze efficacy safety O plus R-CHOP-like (O+R-CHOP) for untreated non-germinal center B-cell-like diffuse large B-cell lymphoma ...

Ovine sarcoptic mange is a contagious ectoparasitic skin disease, seen in many countries with sheep production. Although several studies concerning dermatopathology have been published, the local cutaneous immune response to Sarcoptes scabiei has not studied by immunohistochemistry. The present study aims evaluate immunohistochemically adaptive cellular chronic natural cases extensive gross les...

background and objectives: classic hodgkin lymphoma (chl), anaplastic large cell lymphoma (alcl) and some cases of diffuse large b cell lymphoma (dlbcl) have overlapping morphologic features. since they all represent distinct clinico-pathologic entities, we explored the differential diagnostic impact of immunophenotyping to discriminate between them. materials and methods: we included 61 cases ...

A 10-year-old, male Rottweilerdog was presented to Small Animal Hospital of Tehran University with a history of lethargy, anorexia, weight loss, vomiting, polyuria, polydipsia and blindness. The dog showed symptoms of depression, high body temperature (39.2 ˚C), tachypnea (40 breaths min-1) and cachexia. In ophthalmic examination, bilateral hyphema (hemmorrahge in anterior chamber of...

In the present study, we described cyto-histopathological features and immunophenotyping of the large B-cell lymphoma in an 8-year-old mixed breed dog with applying the World Health Organization (WHO) system of classification of canine lymphomas. In fine-needle aspiration (FNA), lymph nodes were involved by neoplastic cells of intermediate to large size with deep blue cytoplasm; consist of cent...

Primary central nervous system lymphoma (PCNSL) most commonly (>95%) constitutes a specific kind of diffuse large B-cell lymphoma, which shows expression CD20, CD19 and CD79a antigens on its surface belongs to non-germinal center B-cell-like type (non-GCB). This results from both limited localization as well immunophenotypic molecular features. It frequently has an aggressive clinical course...

Fever of unknown origin is always a diagnostic challenge in establishing etiology. A gentleman his 70s presented with complaints fever and dry cough for 2 months duration. We proceeded contrast imaging the thorax abdomen which revealed mild hepatomegaly. Bone marrow examination bone culture 18-fluorodeoxyglucose positron emission tomography/computed tomography (18-FDG PET/CT). aspirate smears w...

Only a few cases of extranodal Epstein-Barr virus (EBV)-associated B-cell lymphomas arising from patients with angioimmunoblastic T-cell lymphoma (AITL) have been described. We report a case of AITL of which secondary cutaneous EBV-associated diffuse large B-cell lymphoma (DLBCL) developed after the initial diagnosis of AITL. A 65-year-old Chinese male patient was diagnosed as AITL based on typ...