BACKGROUND/AIMS The existence of non-celiac gluten sensitivity has been debated. Indeed, the intestinal and extra-intestinal symptoms of many patients with irritable bowel syndrome (IBS) but without celiac disease or wheat allergy have been shown to improve on a gluten-free diet. Therefore, this study set out to evaluate the effects of gluten on IBS symptoms. METHODS We performed a double-bli...

Celiac disease is a chronic enteropathy and immune-mediated of the small intestine that affects about 1.1% to 1.7% world population. Presently effective medical treatment restriction gluten-containing foods. However, economic cost nutritional quality have negatively influenced maintenance gluten-free diet in several countries by consumers. In Brazil, scarcity information on these products point...

BACKGROUND AND AIMS In a previous report, we characterized a condition of gluten sensitivity in juvenile rhesus macaques that is similar in many respects to the human condition of gluten sensitivity, celiac disease. This animal model of gluten sensitivity may therefore be useful toward studying both the pathogenesis and the treatment of celiac disease. Here, we perform two pilot experiments to ...

Celiac disease is an immune-mediated enteropathy triggered by the ingestion of gluten-containing grains (including wheat, rye, and barley) in genetically susceptible persons. The disease is associated with HLA-DQ2 in 90 to 95 percent of cases and with HLA-DQ8 in 5 to 10 percent of cases and is self-perpetuating in the continued presence of gluten. 1 It is the interplay between genes (both HLA a...

Celiac disease is a multisystem resistant based issue that is activated by the ingestion of gluten in hereditarily defenseless people. The predominance of celiac disease has ascended in late decades and is at present around 1% in most Western populaces. The explanation behind this ascent is obscure, albeit natural elements identified with the cleanliness speculation are suspected. The pathophys...

Celiac disease (CD) and type 1 diabetes (T1D) are autoimmune conditions in which dietary gluten has been proven or suggested to play a pathogenic role. In CD; gluten is established as the instigator of autoimmunity; the autoimmune process is halted by removing gluten from the diet; which allows for resolution of celiac autoimmune enteropathy and subsequent normalization of serological markers o...

BACKGROUND AND AIMS Celiac disease is a permanent intolerance to gluten prolamins from wheat, barley, rye and, in some patients, oats. Partially digested gluten peptides produced in the digestive tract cause inflammation of the small intestine. High throughput, immune-based assays using monoclonal antibodies specific for these immunotoxic peptides would facilitate their detection in food and en...

Microscopic enteritis (ME) is characterized by abnormal infiltration of intraepithelial lymphocytes in intestinal mucosa. It was described as duodenal lymphocytosis or lymphocytic duodenitis until the dedicated Consensus Conference of 2015. ME represents a common feature of several gluten-mediated and non-gluten related diseases; therefore, it is an umbrella term embracing several conditions. T...

Some reports have demonstrated an inadequate response to hepatitis B vaccination in patients affected by celiac disease. The aim of our study was to evaluate hepatitis B vaccination response in relation to gluten exposure status in patients with celiac disease. To measure the gluten exposure status at the time of vaccination, we considered three groups: group A (exposed to gluten), including pa...

Introduction and purpose:
 Celiac disease occurs in 1% of the general population. However, many cases remain unrecognized.
 The is a chronic immune-mediated disorder triggered by ingestion gluten that appears individuals with genetic susceptibility. can develop paediatric patients as well adults.
 purpose this review to analyze newest information on characteristics, diagnosis tre...