The most common malignancy of the head and neck region is “oral squamous cell carcinoma” (OSCC) because its low survival rate increasing incidence in some geographic areas. The process invasion metastasis, which noted cancers, requires loss cell-to-cell attachment. It therefore important to identify a marker that would help identification lesions acquire ability transform into OSCC. Cell...

naturally the brain is ineffective in regenerating functional tissue after disease or injury, so to overcome these defects innovative curative strategies such as stem cell transplantation and tissue engineering have to be considered. researchers investigate the use of strategies to attain better functional repair results. one of the important challenges of effective transplantation is the deliv...

Preventing peritoneal implantation of carcinoma cells could prolong ovarian cancer patient remission and survival. Peritoneal cells constitutively express mesothelin, a ligand for CA125 that is expressed by tumor cells. Thus blocking CA125/mesothelin-dependent cell attachment may prevent or delay peritoneal metastatic recurrence. We developed a high-throughput screening system for reagents able...

Pseudomonas aeruginosa is a multi-drug resistant (MDR) human pathogen and known for their biofilm growth making it difficult to eliminate. This research aims determine the effectiveness of water extract melinjo leaf (Gnetum gnemon L) on inhibition cell attachment, degradation using Crystal Violet (CV) Assay. Reasearch results showed that contains saponin, alkaloid, tanin dan steroidal antibacte...

background: surface properties of a biomaterial could be critical in determining biomaterial’s biocompatibility due to the fact that the first interactions between the biological environment and artificial materials are most likely occurred at material’s surface. in this study, the surface properties of a new nanocomposite (nc) polymeric material were modified by combining plasma treatment and ...

Plant surfaces showing hierarchical structuring are frequently found in plant organs such as leaves, petals, fruits and stems. In our study we focus on the level of cell shape and on the level of superimposed microstructuring, leading to hierarchical surfaces if both levels are present. While it has been shown that epicuticular wax crystals and cuticular folds strongly reduce insect attachment,...

Hepadnaviruses do not infect cultured cells, therefore our knowledge of the mechanism of the early stages of virus-cell interaction is rather poor. In this study, we show that dimethylsulfoxide (DMSO)-treated HepG2 hepatoblastoma cells are infected efficiently by serum-derived hepatitis B virus (HBV) as monitored by viral gene expression and replication markers. To measure virus attachment, a v...

In order for osteocytes to perceive mechanical information and regulate bone remodeling accordingly they must be anchored to their extracellular matrix (ECM). To date the nature of this attachment is not understood. Osteocytes are embedded in mineralized bone matrix, but maintain a pericellular space (50-80 nm) to facilitate fluid flow and transport of metabolites. This provides a spatial limit...

Human carcinomas of the pancreas are aggressive tumors which traverse basement membrane barriers during invasion and metastasis. In order to examine the relationship of pancreatic tumor cells to basement membranes, we analyzed and compared the capabilities of four biologically different human pancreatic adenocarcinoma lines to adhere to substrate coated with purified basement membrane constitue...

Previous studies have indicated that SAG1, the major surface molecule of the protozoan parasite Toxoplasma gondii, is an important attachment ligand for the host cell. However, the research data that supports this claim comes largely from studies investigating tachyzoite binding, and not SAG1 binding per se. In this study we successfully developed an in vitro attachment assay to directly evalua...