نتایج جستجو برای: cell genomics
تعداد نتایج: 1708627 فیلتر نتایج به سال:
Increased tumour infiltrating lymphocytes (TILs) is correlated with improved clinical outcomes. We hypothesised high TILs comprised a distinct functional state. In breast cancer (BC), we showed were significantly increased in primary compared to metastatic disease. Using single cell genomics, TIL BC had CD8+ T cells resident memory (TRM) differentiation. patients TRM gene signature expression a...
Quantitative-genetic approaches are often assumed to be restricted to phenotypic characters such as body weight, height, or some measure of shape. However, they apply equally well to molecular traits, such as mRNA and protein abundance. With the recent advent of functional genomics tools (such as microarrays) the power of quantitative genetics is now being widely applied to genomics. Genomics l...
Abstract AIMS Glioblastoma (GBM) is a heterogeneous and aggressive brain tumour that invariably fatal despite maximal treatment. GBM-relevant ‘biomarkers’ (such as known driver-mutations or cell-states) could be used to stratify patients for treatments. However, pairing biomarkers with appropriate therapeutic ‘targets’ challenging. If gene more essential in GBM cells which contain such biomarke...
There is widespread agreement that cancer gene discovery requires high-quality tumor samples. However, whether primary tumors or cultured samples are superior for cancer genomics has been a longstanding subject of debate. This debate has recently become more important because federally funded cancer genomics has been centralized under The Cancer Genome Atlas, which has chosen to focus exclusive...
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