The perception of taste is a prime example complex signal transduction at the subcellular level, involving an intricate network molecular machinery, which can be investigated to great extent by tools provided Computational Molecular Modelling. present review summarises current knowledge on mechanisms root transduction, in particular receptors, highly specialised proteins driving activation/deac...

receptors and proteins are overexpressed in many human cancer cell membranes rather than normal tissues and are considered as the main molecular targets. specific tumor- targeting molecules which have high affinity for these receptors can be valuable tools as carrier molecules for targeted cancer therapy and imaging. pharmacokinetics and bioavailability of diagnostic and therapeutic agents are ...

Natural killer (NK) cells are specialized lymphocytes primarily involved in the response to infection and tumors. NK characterized by presence of specific surface molecules, as well a wide repertoire receptors that impart microenvironment‑dependent effector functions. Among these receptors, Toll‑like (TLRs) can be activated condition either cytotoxic or immunoregulatory phenotype. However, cell...

background: toll like receptors (tlrs) are one of the main components of the innate immune system. it has been reported that expression of these receptors are altered in the female reproductive tract (frt) during menstrual cycle. here we used a fallopian tube epithelial cell line (oe-e6/e7) to evaluate the effect of two sex hormones in modulating tlr expression. materials and methods: in this e...

Receptors and proteins are overexpressed in many human cancer cell membranes rather than normal tissues and are considered as the main molecular targets. Specific tumor- targeting molecules which have high affinity for these receptors can be valuable tools as carrier molecules for targeted cancer therapy and imaging. Pharmacokinetics and bioavailability of diagnostic and therapeutic agents are ...

Background: Chemokines are a family of cytokines initially characterized by their capacity to induce chemotaxis, or directed leukocyte migrations. These receptors are activated by chemotactic cytokines called chemokines. Interactions between chemokines and chemokine receptors also are involved in tumorigenesis, migration and invasion of lymphoma cells.Methods: An English literature search...

Cancer immunotherapy refers to any intervention that leverages the immune system to eliminate a malignancy. Successful cancer immunotherapies generate an anti-cancer response that is systemic, specific, and durable and overcome to the primary limitations of traditional cancer treatment modalities. In this review paper, the effective methods in immune system to treat cancer, such as immunosuppre...

introduction: pro-inflammatory chemokines and cytokines   such as mcp-1 and il6 can activate microglial cells that has found in some neuro-inflammatory disorders. hypoxia activates cerebral endothelial cells to release these pro-inflammatory mediators. we aimed to investigate the anti-hypoxic effects of different doses of some gabaergic agents. materials and methods: we randomly divided 150 mic...