The study of molecular evolution at the level of protein-coding genes often entails comparing large datasets of sequences to infer their evolutionary relationships. Despite the importance of a protein's structure and conformational dynamics to its function and thus its fitness, common phylogenetic methods embody minimal biophysical knowledge of proteins. To underscore the biophysical constraint...

Although descriptions of form have been a mainstay of comparative neuroanatomy, less well explored is the use of quantitative approaches, especially at the cellular level. In the neocortex, many gross and cellular anatomical measures show striking regularities over a wide range of brain sizes. Here we review our recent efforts to accurately characterize these scaling trends and explain them in ...

Characterizing the segmental dynamics of proteins, and intrinsically disordered in particular, is a challenge biophysics.

MARCIN RO ZALSKI, IVETA WACZULIKOVA, JURAJ RIEVAJ, KRISTINA NAGYOVA, MARIA BRYSZEWSKA and CEZARY WATALA* Department of Biophysics and Chemical Physics, Faculty of Mathematics, Physics, and Informatics, Comenius University, Bratislava, Slovak Republic, Laboratory of Haemostatic Disorders, Medical University of óo dz , Department of General Biophysics, Institute of Biophysics, University of óo dz...

This editorial celebrates the re-launch of PMC Biophysics previously published by PhysMath Central, in its new format as BMC Biophysics published by BioMed Central with an expanded scope and Editorial Board. BMC Biophysics will fill its own niche in the BMC series alongside complementary companion journals including BMC Bioinformatics, BMC Medical Physics, BMC Structural Biology and BMC Systems...

study of Mueller matrix decomposition in the backscattering geometry Nirmalya Ghosh, Michael F. G. Wood, and I. Alex Vitkin Division of Biophysics and Bioimaging, Ontario Cancer Institute, University Health Network, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada and Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada Division...