This study evaluated the cellular uptake and cytotoxicity of low permeable Ursolic acid (UA) on cancer cells using niosomes composed span 60 cholesterol. The results showed that addition chitosan increased particle sizes ζ-potentials. UA with layers had higher in HeLa than without chitosan, however, there was no improvement observed for Huh7it cells. Moreover, improved uptake, which clathrin-me...

In a clinical study with oral gemcitabine (2',2'-difluorodeoxycytidine, dFdC), 2',2'-difluorodeoxyuridine (dFdU) was extensively formed and accumulated after multiple oral dosing. Here, we have investigated the in vitro cytotoxicity, cellular uptake, efflux, biotransformation, and nucleic acid incorporation of dFdC and dFdU. Short-term and long-term cytotoxicity assays were used to assess the c...