A model is proposed that is based on certain aspects of senso ry cortex. The basic model is a cellular automaton, where the cells represent small groups of neurons in th e cor tex. All cells ar e locally interconnected with their three nearest neighbours in each direction, a variable set of weights determines the st rength of the connections . The output of the cell is a fun ction of the weight...

Background: Rodents with short reproductive cycle length are the best model for investigation of physiology and molecular aspects of reproductive biology. This study aimed to establish a correlation between histological changes of uterus and ovaries with the vaginal smear. Materials and Methods: 6-8 weeks old virgin Female NMRI mice were submitted to the vaginal smear collection and observed us...

The early development of the cerebral cortex is characterized by neurogenesis, neuronal migration, cellular differentiation and programmed cell death. Cajal-Retzius cells, developing cortical plate neurons and subplate cells form a transient synaptic circuit which may serve as a template for the formation of cortical layers and columns. These three neuronal cell types show distinct electrophysi...

Mitochondrial biochemistry is complex, expanding from oxygen consumption, oxidative phosphorylation, lipid catabolism, heme biosynthesis, to apoptosis, calcium homeostasis, and production of reactive oxygen species, including nitric oxide (NO). The latter molecule is produced by a mitochondrial NO synthase (mtNOS). The rates of consumption and production determine the steady-state concentration...

Once dismissed as just the icing on the cake, sugar molecules are emerging as vital components in life's intricate machinery. Our understanding of their function within the context of the proteins and lipids to which they are attached has matured rapidly, and with it the far reaching clinical implications are becoming understood. Recent advances in high-throughput glycomic techniques, glyco bio...

Comprehensive understanding of nervous systems would require the unambiguous identification of all neuronal cell types, which are distinguished by gene-expression differences, particularly in plasma-membrane receptors and ion channels. Toward this ultimate goal, a recent paper initiated an approach to identify and study divergent neuronal cell types through comparative cellular physiology.

IntroductionOver the past decade, human adipose-derived mesenchymal stem/signaling/stromal cell (ADSC) therapies have become increasingly popular as a biologic treatment for variety of orthopedic conditions. ADSCs represent source stromal cells with properties that allow paracrine and immunomodulatory functions ability to differentiate into various downstream cellular tissues. Before considerin...

RNA modifications, collectively called “epitranscriptome”, change in different cellular states and affect cell behavior. This study aims to elucidate differences the modification pattern of ribosomal representing a contributing factor skin physiology after exposure stress pollution. These factors stochastic damage lead accumulation senescent cells promoting aging. We profiled epitranscriptome r...

Changes in cell-cell and cell-substrate adhesion markers are increasingly used to characterize disease onset progression. However, these relationships depend on both the biochemical molecular association between cells their extracellular matrix, as well biophysical mechanical properties orchestrated by cytoskeletal, membrane matrix components. To fully appreciate role of cell when determining n...