OBJECTIVE To assess the potential of anticholinergic drugs as a cause of non-degenerative mild cognitive impairment in elderly people. DESIGN Longitudinal cohort study. SETTING 63 randomly selected general practices in the Montpellier region of southern France. PARTICIPANTS 372 people aged > 60 years without dementia at recruitment. MAIN OUTCOME MEASURES Anticholinergic burden from drug...

OBJECTIVES The intravenous (IV) injection of tropicamide for non-clinical purposes is a new and widespread drug trend. The aim of this study is to provide the first literature review on the topic. METHODS Relevant literature was identified through a search of MEDLINE, Psycinfo, Google Scholar, conference proceedings and select citations. RESULTS Cases of tropicamide (IV) injection have been...

OBJECTIVES To compare the effect of using different anticholinergic drug scales and different models of cognitive decline in longitudinal studies. DESIGN Longitudinal cohort study. SETTING Outpatient clinics, Quebec, Canada. PARTICIPANTS Individuals aged 60 and older without dementia or depression (n = 102). MEASUREMENTS Using baseline and 1-year follow-up data, four measures of anticho...

BACKGROUND AND PURPOSE Oromandibular dyskinesia (OMD) can occur spontaneously or they can be induced by the conventional dopamine receptor antagonists. Anticholinergic medications have rarely been reported to cause OMD in parkinsonian or non-parkinsonian patients. METHODS We analyzed the clinical features of two parkinsonian and one non-parkinsonian patients who experienced OMD after antichol...

Gastric secretion was stimulated by insulin hypoglycaemia and the effect of increasing doses of anticholinergic drugs on the volume, acid, and electrolyte content of gastric juice was studied. The sodium and potassium output was depressed to a far less extent than the acid output and the drop in volume of secretion and acid output after anticholinergic drugs is almost entirely due to decreased ...

OBJECTIVE To review the efficacy of drug therapy for urinary urge incontinence by examining the published literature. METHODS OF STUDY SELECTION In October 1999, we searched the medical databases MEDLINE, EMBASE, and Cochrane Controlled Trials Register to identify prospective randomized, double-blind, placebo-controlled clinical trials in the English literature evaluating drug therapy (except...

Purpose: False-negative urodynamic findings may mislead or prevent planned treatments due to unmatched with the clinical presentation. We hypothesized that absence of demonstration SUI OAB on urodynamics would interfere outcomes. Materials and Methods: prospectively studied 124 women (94) without (30) demonstrable after sling operations. Similarly, 64 syndrome (38) (26) DO were also compared tr...