Among 777 patients transferred to 4 hospitals in Bangkok from southern Thailand after the tsunami of 26 December 2004, there were 515 with skin and soft-tissue infections. The most common organisms isolated were Aeromonas species (145 [22.6%] of 641 isolates from 305 patients). Most isolates were susceptible to aminoglycosides, third- and fourth-generation cephalosporins, quinolones, and imipen...

BL-S 640 was evaluated in vitro by comparison with cephalothin, cephaloridine, cefazolin, and cephalexin. The new compound was more active than the control cephalosporins against most major gram-negative and some gram-positive species. Moreover, its antibacterial spectrum included strains of Enterobacter, Proteus morganii, P. rettgeri, and Providencia stuartii, species generally resistant to th...

Shigellosis is an important public health problem, especially in developing countries. Antibiotic treatment of dysentery aimed at resolving diarrhea or reducing its duration, and to prevent transmission to other close contacts. Isolates with resistance to first line drugs have been reported throughout world, third generation cephalosporins and quinolones are mainstay of treatment. Shigella flex...

Extended Spectrum Beta Lactamases (ESBL) are enzymes produced in some gram negative bacilli that mediate resistance to extended spectrum cephalosporins. 683 clinical isolates of Escherisia coli and Klebsiella pneumoniae were studied for their capacity to produce ESBL. Isolates showing resistance to at least two of the third generation cephalosporins were studied for ESBL production by Jarlier t...

We report on two cases of pneumococcal infection caused by strains demonstrating high-level cefotaxime resistance (minimal inhibitory concentration, 4 µg/mL). One patient had acute community-acquired meningitis with bacteraemia and the other had bacteraemia probably as a result of nosocomial pneumonia. Both patients died despite treatment with third generation cephalosporins. This is the first ...

polarographic methods have been developed for the determination of two cephalosporins namely cefotaxime (ctx) and ceftriaxone (ctr) in pharmaceutical formulations. well defined peaks at potentials –1.432 v vs. sce for ctx and –1.627 v vs. sce for ctr were obtained in the presence of tungsten (vi). the method has been successfully applied for the determination of above mentioned cephalosporins i...

From a once easily treatable infection, gonorrhoea has evolved into a challenging disease, which in future may become untreatable in certain circumstances. International spread of extensively drug-resistant gonococci would have severe public health implications. It seems clear that under the current treatment pressure from extended-spectrum cephalosporins, and owing to Neisseria gonorrhoeae's r...

The hydrolysis of β-lactam antibiotics by β-lactamases is one of the major bacterial defense systems. These enzymes generally hydrolyze a variety of antibiotics including the latest generation of cephalosporins, cephamycins and imipenem. In this paper, the effect of cephalosporins-based antibiotics on the peroxynitrite-mediated nitration of protein tyrosine is described. Although some of the an...

Minimum inhibitory concentrations have been determined for ampicillin and seven cephalosporins against 93 strains of group D streptococci isolated recently from clinical material. Ampicillin was much the most active compound (modal MIC = 1.6 mug/ml); cephaloridine, cephacetrile, and cefazolin had a modal MIC of 25 mug/ml, while corresponding figures for cephalothin, cephradine, cephalexin, and ...