Abstract Diffuse intrinsic pontine glioma (DIPG) is a rare and incurable pediatric brain cancer with survival of less than one year. Understanding the tumorigenesis mechanisms DIPG identifying potential therapeutic strategy are major research foci in field. The most lethal subtype diffuse H3K27M subtype. Although ACVR1 mutations have been implicated pathogenesis this presently disease, impacts ...

BACKGROUND AND PURPOSE Pontine infarction is most often related to basilar artery atherosclerosis when the lesion abuts on the basal surface (paramedian pontine infarction), whereas small medial pontine lesion is usually attributed to small vessel lipohyalinosis. A previous study has found that high-resolution MRI can detect basilar atherosclerotic plaques in up to 70% of patient with paramedia...

eight patients with gross lesions of the pons as demonstrated by air contrast study as well as cranial nerve, long tract and cerebellar syrnphomatology, were treated with 240 kilovolt x-ray therapy, .receiving 2,750 to 5,000 r. initial dose with palliamon for most of them, another 2,750 to 5,000 r. intial does palliation for most of them. another child received only 600 r. and was not helped. ,...

Diffuse intrinsic pontine glioma (DIPG) kills more children than any other type of brain tumor. Despite clinical trials testing many chemotherapeutic agents, palliative radiotherapy remains the standard treatment. Here, we utilized Cre/loxP technology to show that deleting Ataxia telangiectasia mutated (Atm) in primary mouse models DIPG can enhance tumor radiosensitivity. Genetic deletion Atm i...

In this paper, we present a brief anatomical description of the torus longitudinalis and the valvula cerebelli in a percomorph fish, the gilthead seabream (Sparus aurata) based on the analysis of serial brain sections stained by paraldehyde fuchsin, Groat's hematoxylin-picroindigocarmin and cresyl violet. The existence of a small undescribed fiber tract directly bridging the ventral torus longi...

Formerly known as central pontine myelinolysis, osmotic demyelination syndrome (ODS) is defined by a symmetrical destruction of myelin sheaths involving mainly the central portion of the basis pontis without evidence of vascular involvement. We report the case of a 60-year-old man who presented to the emergency department with a 2-week history of progressive confusion, memory loss, and lower ex...

We present a case of a 57-year-old woman who underwent gamma-knife radiosurgery (GKRS) for pontine metastasis. Magnetic resonance (MR) imaging 2.8 months after GKRS showed T₂ hyperintensity and hypertrophy of the left inferior olivary nucleus (ION) without gadolinium enhancement and smaller pontine metastasis. We diagnosed the signal change in the left ION as hypertrophic olivary degeneration (...